干旱区生态环境知识资源中心(Arid): Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs

Arid

DOI	10.1208/s12249-020-01879-7
	Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs
	Patki, Manali; Palekar, Siddhant; Nukala, Pavan Kumar; Vartak, Richa; Patel, Ketankumar
通讯作者	Patki, M
来源期刊	AAPS PHARMSCITECH
ISSN	1530-9932
出版年	2021
卷号	22 期号:1
英文摘要	Death from an accidental or intentional overdose of sleeping tablets has increased exponentially in the USA. Furthermore, the simultaneous consumption of sleeping tablets with alcoholic beverages not only intensifies the effect of sleeping tablets but also leads to blackouts, sleepwalking, and death in many cases. In this article, we proposed a unique and innovative technology to prevent multi-tablet and alcohol-associated abuse of sleeping tablet. Agonist- and antagonist-loaded polymeric filaments of appropriate Eudragit (R) polymers were prepared using hot melt extrusion. Metoprolol tartrate and hydrochlorothiazide were used as model drugs in place of zolpidem tartrate (agonist-BCS class I) and flumazenil (antagonist-BCS class IV), respectively. Crushed filaments were converted into a tablet with a novel rapidly soluble co-processed alkalizing agent. Dissolution studies of single tablet and multiple tablets (5) in fasted state simulated gastric fluid (FaSSGF) confirmed that the release of the agonist was significantly (p < 0.0001) reduced in multi-tablet dissolution. Furthermore, the release of antagonist was significantly higher when tablet was exposed to FaSSGF+20% ethanol and various alcoholic beverages. Thus, appropriate use of Eudragit (R) polymer's chemistry could help design a tablet to prevent the release of agonist in case of overdose and simultaneous release of antagonist when consumed with alcohol.
英文关键词	sleeping tablet zolpidem drug abuse hot melt extrusion Eudragit polymer abuse-deterrent formulation
类型	Article
语种	英语
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000595721100003
WOS关键词	ZOLPIDEM ; FORMULATION ; FLUMAZENIL ; DEPENDENCE ; RESISTANT ; DESIGN ; MISUSE
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/328053
作者单位	[Patki, Manali; Palekar, Siddhant; Nukala, Pavan Kumar; Vartak, Richa; Patel, Ketankumar] St Johns Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, Queens, NY 11439 USA
推荐引用方式 GB/T 7714	Patki, Manali,Palekar, Siddhant,Nukala, Pavan Kumar,et al. Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs[J],2021,22(1).
APA	Patki, Manali,Palekar, Siddhant,Nukala, Pavan Kumar,Vartak, Richa,&Patel, Ketankumar.(2021).Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs.AAPS PHARMSCITECH,22(1).
MLA	Patki, Manali,et al."Overdose and Alcohol Sensitive Immediate Release System (OASIS) for Deterring Accidental Overdose or Abuse of Drugs".AAPS PHARMSCITECH 22.1(2021).