干旱区生态环境知识资源中心(Arid): Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment

Arid

DOI	10.3803/EnM.2020.35.2.443
	Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment
	Sulaieva, Oksana; Chernenko, Olena; Selesnov, Oleksiy; Nechay, Oleksandr; Maievskyi, Oleksandr; Falalyeyeva, Tetyana; Kobyliak, Nazarii; Tsyryuk, Olena; Penchuk, Yurii; Shapochka, Dmytro
通讯作者	Kobyliak, N
来源期刊	ENDOCRINOLOGY AND METABOLISM
ISSN	2093-596X
EISSN	2093-5978
出版年	2020
卷号	35 期号:2 页码:443-455
英文摘要	Background: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains uncertain. We assessed the impact of HT on the tumor immune microenvironment (TIME) in PTC. Methods: Thirty patients with PTC (group 1) and 30 patients with PTC and HT (group 2) were enrolled in this pilot study. The distribution and number of CD8+ lymphocytes, plasma cells (CD138+), regulatory T cells (forkhead box P3 [FOXP3+)], mast cell tryptase (MCT+), and M2 macrophages (CD163+) were evaluated. To test the hypothesis that HT impacts PTC development via signal transducer and activator of transcription 6 (STAT6) activation and M2 macrophage polarization, we investigated STAT6 expression in tumor and stromal cells. We also evaluated vascular endothelial growth factor (VEGF) expression by lymph node metastasis (LNM) status. Results: TIME showed significant between-group differences. Group 1 patients demonstrated immune desert or immune-excluded immunophenotypes, while an inflamed phenotype with more CD8+ cells (P<0.001) predominated in group 2. Immune-excluded TIME was associated with the highest LNM rate. In PTC, LNM was associated with more numerous CD163+ cells. Moreover, LNM in group 1 was associated with increased numbers of mast cells peritumorally and FOXP3+ cells intratumorally and peritumorally. Group 2 demonstrated higher STAT6 but not higher VEGF expression in tumor cells. High VEGF expression was associated with LNM regardless of HT status. Conclusion: Concomitant HT impacted PTC signaling via STAT6 and TIME by increasing the number of CD8+ cells. LNM is associated with increases in CD163+ cells and VEGF expression in PTC, whereas HT affected LNM through different mechanisms.
英文关键词	Thyroid cancer papillary Hashimoto disease Metastasis T-lymphocytes Macrophages
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000596724000026
WOS关键词	MACROPHAGES ; CANCER ; CELLS ; LYMPHOCYTES ; ACTIVATION ; PARTNERS ; GROWTH
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327872
作者单位	[Sulaieva, Oksana; Selesnov, Oleksiy; Shapochka, Dmytro] Lab Pathol CSD Hlth Care, Kiev, Ukraine; [Chernenko, Olena; Nechay, Oleksandr] Ukrainian Res & Pract Ctr Endocrine Surg, Kiev, Ukraine; [Maievskyi, Oleksandr; Falalyeyeva, Tetyana; Tsyryuk, Olena; Penchuk, Yurii] Taras Shevchenko Natl Univ Kyiv, Inst Biol & Med, Kiev, Ukraine; [Kobyliak, Nazarii] Bogomolets Natl Med Univ, Dept Endocrinol, Pushkinska 22a St, UA-01601 Kiev, Ukraine
推荐引用方式 GB/T 7714	Sulaieva, Oksana,Chernenko, Olena,Selesnov, Oleksiy,et al. Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment[J],2020,35(2):443-455.
APA	Sulaieva, Oksana.,Chernenko, Olena.,Selesnov, Oleksiy.,Nechay, Oleksandr.,Maievskyi, Oleksandr.,...&Shapochka, Dmytro.(2020).Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment.ENDOCRINOLOGY AND METABOLISM,35(2),443-455.
MLA	Sulaieva, Oksana,et al."Mechanisms of the Impact of Hashimoto Thyroiditis on Papillary Thyroid Carcinoma Progression: Relationship with the Tumor Immune Microenvironment".ENDOCRINOLOGY AND METABOLISM 35.2(2020):443-455.