干旱区生态环境知识资源中心(Arid): Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes

Arid

DOI	10.1038/s41698-020-00135-2
	Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes
	Ling, Yun; Li, Ning; Li, Lin; Guo, Changyuan; Wei, Jiacong; Yuan, Pei; Tan, Fengwei; Tao, Xiuli; Wang, Shuhang; Wang, Zhijie; Wu, Ning; Wang, Jie; Ying, Jianming; Gao, Shugeng; He, Jie
通讯作者	Ying, JM
来源期刊	NPJ PRECISION ONCOLOGY
EISSN	2397-768X
出版年	2020
卷号	4 期号:1
英文摘要	Neoadjuvant immunotherapy provides a unique opportunity for understanding therapeutic responses. We analyzed pathologic responses in surgical specimens obtained from 31 squamous non-small cell lung cancer (NSCLC) patients receiving neoadjuvant anti-PD-1 treatment. Fifteen (48.4%) patients achieved pathologic complete response (pCR) or major pathologic response (MPR). Among them, seven (46.7%) were assessed as radiological partial response and eight (53.3%) as stable disease. Among 20 patients with pathologically identified tumor beds in lymph nodes (LNs), 10 and six patients achieved pCR/MPR in primary tumors and paired LNs, respectively. pCR was achieved in 6/19 N1 nodes and 1/7 N2 nodes. Residual viable tumor (RVT) cells in 8/9 MPR specimens had 100% immune-activated phenotype, while a median of 80% of RVT cells in pathologic nonresponse specimens presented immune-excluded/desert phenotype. These findings demonstrated that assessment of pathologic responses in both primary tumor and LNs may be important as a surrogate for assessing neoadjuvant immunotherapeutic efficacy.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000596045300001
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327861
作者单位	[Ling, Yun; Li, Lin; Guo, Changyuan; Wei, Jiacong; Yuan, Pei; Ying, Jianming] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Pathol, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China; [Li, Ning; Wang, Shuhang] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Clin Canc Ctr, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China; [Tan, Fengwei; Gao, Shugeng; He, Jie] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Thorac Surg, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China; [Tao, Xiuli; Wu, Ning] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept PET CT Ctr, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China; [Wang, Zhijie; Wang, Jie] Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Dept Med Oncol, Natl Canc Ctr,Canc Hosp, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Ling, Yun,Li, Ning,Li, Lin,et al. Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes[J],2020,4(1).
APA	Ling, Yun.,Li, Ning.,Li, Lin.,Guo, Changyuan.,Wei, Jiacong.,...&He, Jie.(2020).Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes.NPJ PRECISION ONCOLOGY,4(1).
MLA	Ling, Yun,et al."Different pathologic responses to neoadjuvant anti-PD-1 in primary squamous lung cancer and regional lymph nodes".NPJ PRECISION ONCOLOGY 4.1(2020).