干旱区生态环境知识资源中心(Arid): Simultaneous determination of 11 illicit drugs and metabolites in wastewater by UPLC-MS/MS

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DOI	10.2166/wst.2020.445
	Simultaneous determination of 11 illicit drugs and metabolites in wastewater by UPLC-MS/MS
	Yuan, Shuai; Wang, Xin; Wang, Roujia; Luo, Ruxin; Shi, Yan; Shen, Baohua; Liu, Wei; Yu, Zhiguo; Xiang, Ping
通讯作者	Yu, ZG
来源期刊	WATER SCIENCE AND TECHNOLOGY
ISSN	0273-1223
EISSN	1996-9732
出版年	2020
卷号	82 期号:9 页码:1771-1780
英文摘要	Assessing collective drug consumption based on the concentrations of illicit drugs and their metabolites in wastewater is a new technology. Currently, this technology is receiving attention in China, and methods for multiple illicit drug detection in wastewater are urgently needed. In our study, a method with a short runtime (7 min), a small solid-phase extraction (SPE) loading volume (50 mL) and high sensitivity (lower limits of quantitation (LLOQs) ranged from 0.2 to 5 ng/L) was developed for the simultaneous determination of amphetamines, ketamine, opiates, cocaine and their metabolites in wastewater. Samples were enriched by SPE on a mixed-mode sorbent (Oasis MCX) and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The limits of detection (LODs) ranged from 0.1 to 2 ng/L, and the LLOQs varied between 0.2 and 5 ng/L. Moreover, the method developed was applied to real wastewater samples collected from 15 different wastewater treatment plants (WWTPs). In the results, the most abundant compounds were morphine (1.8-46.6 ng/L) and codeine (3.7-24.9 ng/L), which were detected in 13 WWTPs. After successful optimization of the UPLC-MS/MS conditions and sample loading pH, the method developed is able to meet the needs of common illicit drug monitoring and high-throughput analysis requirements.
英文关键词	illicit drugs solid-phase extraction ultra-performance liquid chromatography-tandem mass spectrometry wastewater
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000595253000004
WOS关键词	PROXIMAL GASTRECTOMY ; CONSUMPTION TRENDS ; METHAMPHETAMINE ; AMPHETAMINE ; ABUSE ; PHARMACEUTICALS ; RESIDUES ; COCAINE
WOS类目	Engineering, Environmental ; Environmental Sciences ; Water Resources
WOS研究方向	Engineering ; Environmental Sciences & Ecology ; Water Resources
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327818
作者单位	[Yuan, Shuai; Wang, Roujia; Yu, Zhiguo] Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China; [Yuan, Shuai; Wang, Xin; Wang, Roujia; Luo, Ruxin; Shi, Yan; Shen, Baohua; Liu, Wei; Xiang, Ping] Minist Justice, Shanghai Key Lab Forens Med, Acad Forens Sci, Dept Forens Toxicol, 1347 Guangfu Xi Rd, Shanghai 200063, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Shuai,Wang, Xin,Wang, Roujia,et al. Simultaneous determination of 11 illicit drugs and metabolites in wastewater by UPLC-MS/MS[J],2020,82(9):1771-1780.
APA	Yuan, Shuai.,Wang, Xin.,Wang, Roujia.,Luo, Ruxin.,Shi, Yan.,...&Xiang, Ping.(2020).Simultaneous determination of 11 illicit drugs and metabolites in wastewater by UPLC-MS/MS.WATER SCIENCE AND TECHNOLOGY,82(9),1771-1780.
MLA	Yuan, Shuai,et al."Simultaneous determination of 11 illicit drugs and metabolites in wastewater by UPLC-MS/MS".WATER SCIENCE AND TECHNOLOGY 82.9(2020):1771-1780.