干旱区生态环境知识资源中心(Arid): Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes

Arid

DOI	10.3390/molecules25225365
	Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes
	Law, Jodi Woan-Fei; Law, Lydia Ngiik-Shiew; Letchumanan, Vengadesh; Tan, Loh Teng-Hern; Wong, Sunny Hei; Chan, Kok-Gan; Ab Mutalib, Nurul-Syakima; Lee, Learn-Han
通讯作者	Lee, LH
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2020
卷号	25 期号:22
英文摘要	Worldwide cancer incidence and mortality have always been a concern to the community. The cancer mortality rate has generally declined over the years; however, there is still an increased mortality rate in poorer countries that receives considerable attention from healthcare professionals. This suggested the importance of the prompt detection, effective treatment, and prevention strategies. The genus Streptomyces has been documented as a prolific producer of biologically active secondary metabolites. Streptomycetes from mangrove environments attract researchers' attention due to their ability to synthesize diverse, interesting bioactive metabolites. The present review highlights research on mangrove-derived streptomycetes and the production of anticancer-related compounds from these microorganisms. Research studies conducted between 2008 and 2019, specifically mentioning the isolation of streptomycetes from mangrove areas and described the successful purification of compound(s) or generation of crude extracts with cytotoxic activity against human cancer cell lines, were compiled in this review. It is anticipated that there will be an increase in prospects for mangrove-derived streptomycetes as one of the natural resources for the isolation of chemotherapeutic agents.
英文关键词	mangrove anticancer cytotoxic bioactive Streptomyces
类型	Review
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000594923600001
WOS关键词	COMPLETE GENOME SEQUENCE ; NATURAL-PRODUCTS ; SP NOV. ; MARINE ACTINOMYCETE ; CIGARETTE-SMOKING ; ATACAMA DESERT ; GENE CLUSTERS ; CANCER ; DIVERSITY ; ACTINOBACTERIA
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327805
作者单位	[Law, Jodi Woan-Fei; Letchumanan, Vengadesh; Tan, Loh Teng-Hern; Lee, Learn-Han] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Novel Bacteria & Drug Discovery NBDD Res Grp, Microbiome & Bioresource Res Strength, Bandar Sunway 47500, Selangor Darul, Malaysia; [Law, Lydia Ngiik-Shiew] Monash Univ, Fac Pharm & Pharmaceut Sci, Monash Credentialed Pharm Clin Educator, 381 Royal Parade, Parkville, Vic 3052, Australia; [Wong, Sunny Hei] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China; [Chan, Kok-Gan] Univ Malaya, Fac Sci, Inst Biol Sci, Div Genet & Mol Biol, Kuala Lumpur 50603, Malaysia; [Chan, Kok-Gan] Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China; [Ab Mutalib, Nurul-Syakima] Univ Kebangsaan Malaysia, UKM Med Ctr, UKM Med Mol Biol Inst UMBI, Kuala Lumpur 56000, Malaysia
推荐引用方式 GB/T 7714	Law, Jodi Woan-Fei,Law, Lydia Ngiik-Shiew,Letchumanan, Vengadesh,et al. Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes[J],2020,25(22).
APA	Law, Jodi Woan-Fei.,Law, Lydia Ngiik-Shiew.,Letchumanan, Vengadesh.,Tan, Loh Teng-Hern.,Wong, Sunny Hei.,...&Lee, Learn-Han.(2020).Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes.MOLECULES,25(22).
MLA	Law, Jodi Woan-Fei,et al."Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes".MOLECULES 25.22(2020).