Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.3390/molecules25225365 |
Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes | |
Law, Jodi Woan-Fei; Law, Lydia Ngiik-Shiew; Letchumanan, Vengadesh; Tan, Loh Teng-Hern; Wong, Sunny Hei; Chan, Kok-Gan; Ab Mutalib, Nurul-Syakima; Lee, Learn-Han | |
通讯作者 | Lee, LH |
来源期刊 | MOLECULES
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EISSN | 1420-3049 |
出版年 | 2020 |
卷号 | 25期号:22 |
英文摘要 | Worldwide cancer incidence and mortality have always been a concern to the community. The cancer mortality rate has generally declined over the years; however, there is still an increased mortality rate in poorer countries that receives considerable attention from healthcare professionals. This suggested the importance of the prompt detection, effective treatment, and prevention strategies. The genus Streptomyces has been documented as a prolific producer of biologically active secondary metabolites. Streptomycetes from mangrove environments attract researchers' attention due to their ability to synthesize diverse, interesting bioactive metabolites. The present review highlights research on mangrove-derived streptomycetes and the production of anticancer-related compounds from these microorganisms. Research studies conducted between 2008 and 2019, specifically mentioning the isolation of streptomycetes from mangrove areas and described the successful purification of compound(s) or generation of crude extracts with cytotoxic activity against human cancer cell lines, were compiled in this review. It is anticipated that there will be an increase in prospects for mangrove-derived streptomycetes as one of the natural resources for the isolation of chemotherapeutic agents. |
英文关键词 | mangrove anticancer cytotoxic bioactive Streptomyces |
类型 | Review |
语种 | 英语 |
开放获取类型 | Green Published, gold |
收录类别 | SCI-E |
WOS记录号 | WOS:000594923600001 |
WOS关键词 | COMPLETE GENOME SEQUENCE ; NATURAL-PRODUCTS ; SP NOV. ; MARINE ACTINOMYCETE ; CIGARETTE-SMOKING ; ATACAMA DESERT ; GENE CLUSTERS ; CANCER ; DIVERSITY ; ACTINOBACTERIA |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/327805 |
作者单位 | [Law, Jodi Woan-Fei; Letchumanan, Vengadesh; Tan, Loh Teng-Hern; Lee, Learn-Han] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Novel Bacteria & Drug Discovery NBDD Res Grp, Microbiome & Bioresource Res Strength, Bandar Sunway 47500, Selangor Darul, Malaysia; [Law, Lydia Ngiik-Shiew] Monash Univ, Fac Pharm & Pharmaceut Sci, Monash Credentialed Pharm Clin Educator, 381 Royal Parade, Parkville, Vic 3052, Australia; [Wong, Sunny Hei] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China; [Chan, Kok-Gan] Univ Malaya, Fac Sci, Inst Biol Sci, Div Genet & Mol Biol, Kuala Lumpur 50603, Malaysia; [Chan, Kok-Gan] Jiangsu Univ, Int Genome Ctr, Zhenjiang 212013, Jiangsu, Peoples R China; [Ab Mutalib, Nurul-Syakima] Univ Kebangsaan Malaysia, UKM Med Ctr, UKM Med Mol Biol Inst UMBI, Kuala Lumpur 56000, Malaysia |
推荐引用方式 GB/T 7714 | Law, Jodi Woan-Fei,Law, Lydia Ngiik-Shiew,Letchumanan, Vengadesh,et al. Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes[J],2020,25(22). |
APA | Law, Jodi Woan-Fei.,Law, Lydia Ngiik-Shiew.,Letchumanan, Vengadesh.,Tan, Loh Teng-Hern.,Wong, Sunny Hei.,...&Lee, Learn-Han.(2020).Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes.MOLECULES,25(22). |
MLA | Law, Jodi Woan-Fei,et al."Anticancer Drug Discovery from Microbial Sources: The Unique Mangrove Streptomycetes".MOLECULES 25.22(2020). |
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