干旱区生态环境知识资源中心(Arid): Anti-Microbial, Anti-Oxidant, and alpha-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora

Arid

DOI	10.3390/molecules25225457
	Anti-Microbial, Anti-Oxidant, and alpha-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora
	Al-Omar, Mohsen S.; Mohammed, Hamdoon A.; Mohammed, Salman A. A.; Abd-Elmoniem, Essam; Kandil, Yasser I.; Eldeeb, Hussein M.; Chigurupati, Sridevi; Sulaiman, Ghassan M.; Al-Khurayyif, Hadeel K.; Almansour, Basma S.; Suryavamshi, Prarthana M.; Khan, Riaz A.
通讯作者	Khan, RA
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2020
卷号	25 期号:22
英文摘要	Halophytes are the category of plants growing under harsh conditions of super-salinity, and are wide-spread in the coastal Mediterranean climatic conditions and desert oasis. They are adept at surviving through maintaining excessive production of enzymatic, and non-enzymatic secondary metabolites, especially phenolics and flavonoids that primarily work as anti-oxidants and phytoalexins. Five major halophyte species growing in the kingdom's Qassim's high-salted desert regions were investigated for confirming their traditionally used biological activity of sugar-control and anti-infectious properties. In this context, the comparative presence of phenolics, and flavonoids together with anti-microbial, anti-oxidants, and the anti-diabetic potentials of the plants' extracts were investigated through the alpha-amylase inhibition method. The highest concentrations of phenolics and flavonoids were detected in Salsola imbricata (360 mg/g of the extract as Gallic-Acid-Equivalents/GAE, and 70.5 mg/g of the extract as Rutin-Equivalents/RE). In contrast, the lowest concentrations of phenolics and flavonoids were detected in Salsola cyclophylla (126.6 mg/g GAE, and 20.5 mg/g RE). The halophytes were found rich in trace elements, a factor for water-retention in high-salinity plants, wherein iron and zinc elements were found comparatively in higher concentrations in Aeluropus lagopoides (4113 mu g/kg, and 40.1 mu g/kg, respectively), while the copper was detected in higher concentration (11.1 mu g/kg) in S. imbricata, analyzed through Inductively Coupled Plasma Optical Emission Spectrometric (ICP-OES) analysis. The anti-oxidant potentials and alpha-amylase enzyme inhibition-based anti-diabetic activity of S. imbricata was significantly higher than the other halophytes under study, wherein S. cyclophylla exhibited the lowest level of alpha-amylase inhibition. The maximum DPPH radicals' (52.47 mg/mL), and alpha-amylase inhibitions (IC50 22.98 mu g/mL) were detected in A. lagopoides. The anti-microbial activity against the Methicillin-Resistant Staphylococcus aureus was strongly exhibited by Zygophyllum simplex (33 mm Inhibition Zone-Diameter, 50 mu g/mL Minimum-Inhibitory-Concentration), while Escherichia coli, Enterococcus faecalis, and Candida albicans growths were moderately inhibited by Tamarix aphylla. The current findings exhibited significant differences among the locally distributed halophytic plants species with regards to their bioactivity levels, anti-oxidant potentials, and the presence of trace elements. The ongoing data corroborated the plants' traditional uses in infections and diabetic conditions. The enhanced local distribution of the plants' diaspora and higher density of occurrence of these plants species in this region, in comparison to their normal climatic condition's counterparts, seemed to be affected by humans' use of the species as part of the traditional and alternative medicine over a period of long time.
英文关键词	total phenolics flavonoids phenols trace elements anti-oxidant anti-microbial α -amylase enzyme inhibition anti-diabetics halophytes Aeluropus lagopoides Salsola cyclophylla Salsola imbricata Tamarix aphylla Zygophyllum simplex methicillin resistance Staphylococcus aureus (MRSA)
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000594170200001
WOS关键词	FLAVONOID CONTENT ; PHENOL ; IRON
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327763
作者单位	[Al-Omar, Mohsen S.; Mohammed, Hamdoon A.; Chigurupati, Sridevi; Almansour, Basma S.; Khan, Riaz A.] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Qasim 51452, Saudi Arabia; [Al-Omar, Mohsen S.] JUST, Fac Pharm, Med Chem & Pharmacognosy Dept, Irbid 22110, Jordan; [Mohammed, Hamdoon A.] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11371, Egypt; [Mohammed, Salman A. A.; Eldeeb, Hussein M.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Qasim 51452, Saudi Arabia; [Abd-Elmoniem, Essam] Qassim Univ, Coll Agr & Vet Med, Dept Plant Prod & Protect, Qasim 51452, Saudi Arabia; [Kandil, Yasser I.] Al Azhar Univ, Fac Pharm, Biochem & Mol Biol Dept, Cairo 11231, Egypt; [Kandil, Yasser I.] Al Ahliyya Amman Univ, Fac Pharm, Pharmacol & Diagnost Res Ctr, Amman 19328, Jordan; [Eldeeb, Hussein M.] Al Azhar Univ, Fac Med, Dept Biochem, Assiut 71524, Egypt; [Sulaiman, Ghassan M.] Univ Technol Baghdad, Dept Appl Sci, Div Biotechnol, Baghdad 35010, Iraq; [Al-Khurayyif, Hadeel K.] Qassim Univ, Coll Pharm, Q...
推荐引用方式 GB/T 7714	Al-Omar, Mohsen S.,Mohammed, Hamdoon A.,Mohammed, Salman A. A.,et al. Anti-Microbial, Anti-Oxidant, and alpha-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora[J],2020,25(22).
APA	Al-Omar, Mohsen S..,Mohammed, Hamdoon A..,Mohammed, Salman A. A..,Abd-Elmoniem, Essam.,Kandil, Yasser I..,...&Khan, Riaz A..(2020).Anti-Microbial, Anti-Oxidant, and alpha-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora.MOLECULES,25(22).
MLA	Al-Omar, Mohsen S.,et al."Anti-Microbial, Anti-Oxidant, and alpha-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora".MOLECULES 25.22(2020).