干旱区生态环境知识资源中心(Arid): The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness

Arid

DOI	10.1371/journal.pone.0242427
	The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness
	Keledjian, Kaspar; Tsymbalyuk, Orest; Semick, Stephen; Moyer, Mitchell; Negoita, Serban; Kim, Kevin; Ivanova, Svetlana; Gerzanich, Volodymyr; Simard, J. Marc
通讯作者	Simard, JM
来源期刊	PLOS ONE
ISSN	1932-6203
出版年	2020
卷号	15 期号:11
英文摘要	Background Gulf War (GW) Illness (GWI) is a debilitating condition with a complex constellation of immune, endocrine and neurological symptoms, including cognitive impairment, anxiety and depression. We studied a novel model of GWI based on 3 known common GW exposures (GWE): (i) intranasal lipopolysaccharide, to which personnel were exposed during desert sand storms; (ii) pyridostigmine bromide, used as prophylaxis against chemical warfare; and (iii) chronic unpredictable stress, an inescapable element of war. We used this model to evaluate prophylactic treatment with the PPAR gamma agonist, rosiglitazone (ROSI). Methods Rats were subjected to the three GWE for 33 days. In series 1 and 2, male and female GWE-rats were compared to naive rats. In series 3, male rats with GWE were randomly assigned to prophylactic treatment with ROSI (GWE-ROSI) or vehicle. After the 33-day exposures, three neurofunctional domains were evaluated: cognition (novel object recognition), anxiety-like behaviors (elevated plus maze, open field) and depression-like behaviors (coat state, sucrose preference, splash test, tail suspension and forced swim). Brains were analyzed for astrocytic and microglial activation and neuroinflammation (GFAP, Iba1, tumor necrosis factor and translocator protein). Neurofunctional data from rats with similar exposures were pooled into 3 groups: naive, GWE and GWE-ROSI. Results Compared to naive rats, GWE-rats showed significant abnormalities in the three neurofunctional domains, along with significant neuroinflammation in amygdala and hippocampus. There were no differences between males and females with GWE. GWE-ROSI rats showed significant attenuation of neuroinflammation and of some of the neurofunctional abnormalities. Conclusion This novel GWI model recapitulates critical neurofunctional abnormalities reported by Veterans with GWI. Concurrent prophylactic treatment with ROSI was beneficial in this model.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000593949800023
WOS关键词	TAIL SUSPENSION TEST ; AL-ESKAN-DISEASE ; PROTEIN 18 KDA ; COGNITIVE IMPAIRMENT ; MOUSE MODEL ; CYCLOPENTENONE PROSTAGLANDINS ; ANTIDEPRESSANT ACTIVITY ; PYRIDOSTIGMINE BROMIDE ; CORTICOSTERONE PRIMES ; GENE-EXPRESSION
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327739
作者单位	[Keledjian, Kaspar; Tsymbalyuk, Orest; Semick, Stephen; Moyer, Mitchell; Negoita, Serban; Kim, Kevin; Ivanova, Svetlana; Gerzanich, Volodymyr; Simard, J. Marc] Univ Maryland, Dept Neurosurg, Sch Med, Baltimore, MD 21201 USA; [Simard, J. Marc] Univ Maryland, Dept Pathol, Sch Med, Baltimore, MD 21201 USA; [Simard, J. Marc] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA; [Simard, J. Marc] Vet Affairs Maryland Hlth Care Syst, Neurosurg Serv, Baltimore, MD 21201 USA
推荐引用方式 GB/T 7714	Keledjian, Kaspar,Tsymbalyuk, Orest,Semick, Stephen,et al. The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness[J],2020,15(11).
APA	Keledjian, Kaspar.,Tsymbalyuk, Orest.,Semick, Stephen.,Moyer, Mitchell.,Negoita, Serban.,...&Simard, J. Marc.(2020).The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness.PLOS ONE,15(11).
MLA	Keledjian, Kaspar,et al."The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, rosiglitazone, ameliorates neurofunctional and neuroinflammatory abnormalities in a rat model of Gulf War Illness".PLOS ONE 15.11(2020).