干旱区生态环境知识资源中心(Arid): Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study

Arid

DOI	10.1093/schbul/sbaa040
	Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study
	Fusar-Poli, Paolo; De Micheli, Andrea; Patel, Rashmi; Signorini, Lorenzo; Miah, Syed; Spencer, Thomas; McGuire, Philip
通讯作者	Fusar-Poli, P
来源期刊	SCHIZOPHRENIA BULLETIN
ISSN	0586-7614
EISSN	1745-1701
出版年	2020
卷号	46 期号:5 页码:1114-1125
英文摘要	The objective of this study is to describe the 2-year real-world clinical outcomes after transition to psychosis in patients at clinical high-risk. The study used the clinical electronic health record cohort study including all patients receiving a first index primary diagnosis of nonorganic International Classification of Diseases (ICD)-10 psychotic disorder within the early psychosis pathway in the South London and Maudsley (SLaM) National Health Service (NHS) Trust from 2001 to 2017. Outcomes encompassed: cumulative probability (at 3, 6, 12, and 24 months) of receiving a first (1) treatment with antipsychotic, (2) informal admission, (3) compulsory admission, and (4) treatment with clozapine and (5) numbers of days spent in hospital (at 12 and 24 months) in patients transitioning to psychosis from clinical high-risk services (Outreach and Support in south London; OASIS) compared to other first-episode groups. Analyses included logistic and 0-inflated negative binomial regressions. In the study, 1561 patients were included; those who had initially been managed by OASIS and had subsequently transitioned to a first episode of psychosis (n = 130) were more likely to receive antipsychotic medication (at 3, 6, and 24 months; all P < .023), to be admitted informally (at all timepoints, all P < .004) and on a compulsory basis (at all timepoints, all P < .013), and to have spent more time in hospital (all timepoints, all P < .007) than first-episode patients who were already psychotic when seen by the OASIS service (n = 310), or presented to early intervention services (n = 1121). The likelihood of receiving clozapine was similar across all groups (at 12/24 months, all P < .101). Transition to psychosis from a clinical high-risk state is associated with severe real-world clinical outcomes. Prevention of transition to psychosis should remain a core target of future research. The study protocol was registered on www.researchregistry.com; researchregistry5039).
英文关键词	psychosis neuroimaging neuroscience
类型	Article
语种	英语
开放获取类型	Green Submitted, Green Published, Bronze
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000593174100014
WOS关键词	ULTRA-HIGH RISK ; 1ST EPISODE PSYCHOSIS ; PREDICTION ; PEOPLE ; OASIS ; STATE ; INTERVENTIONS ; PREVENTION ; DISORDERS ; ONSET
WOS类目	Psychiatry
WOS研究方向	Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327688
作者单位	[Fusar-Poli, Paolo; De Micheli, Andrea; Signorini, Lorenzo; Miah, Syed] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect Lab, London, England; [Fusar-Poli, Paolo; De Micheli, Andrea; Spencer, Thomas; McGuire, Philip] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England; [Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy; [Fusar-Poli, Paolo; McGuire, Philip] South London & Maudsley NHS Fdn Trust, Maudsley Biomed Res Ctr, Natl Inst Hlth Res, London, England; [Patel, Rashmi; Spencer, Thomas; McGuire, Philip] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England; [Fusar-Poli, Paolo; De Micheli, Andrea; Signorini, Lorenzo; Miah, Syed] Kings Coll London, Inst Psychiat Psychol & Neurosci, 5th Floor,PO63,16 De Crespigny Pk, London SE5 8AF, England
推荐引用方式 GB/T 7714	Fusar-Poli, Paolo,De Micheli, Andrea,Patel, Rashmi,et al. Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study[J]. University of London,2020,46(5):1114-1125.
APA	Fusar-Poli, Paolo.,De Micheli, Andrea.,Patel, Rashmi.,Signorini, Lorenzo.,Miah, Syed.,...&McGuire, Philip.(2020).Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study.SCHIZOPHRENIA BULLETIN,46(5),1114-1125.
MLA	Fusar-Poli, Paolo,et al."Real-World Clinical Outcomes Two Years After Transition to Psychosis in Individuals at Clinical High Risk: Electronic Health Record Cohort Study".SCHIZOPHRENIA BULLETIN 46.5(2020):1114-1125.