干旱区生态环境知识资源中心(Arid): Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications

Arid

DOI	10.1093/molbev/msaa123
	Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications
	Touceda-Suarez, Maria; Kita, Elizabeth M.; Acemel, Rafael D.; Firbas, Panos N.; Magri, Marta S.; Naranjo, Silvia; Tena, Juan J.; Gomez-Skarmeta, Jose Luis; Maeso, Ignacio; Irimia, Manuel
通讯作者	Irimia, M
来源期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
EISSN	1537-1719
出版年	2020
卷号	37 期号:10 页码:2857-2864
英文摘要	We investigated how the two rounds of whole-genome duplication that occurred at the base of the vertebrate lineage have impacted ancient microsyntenic associations involving developmental regulators (known as genomic regulatory blocks, GRBs). We showed that the majority of GRBs identified in the last common ancestor of chordates have been maintained as a single copy in humans. We found evidence that dismantling of the duplicated GRB copies occurred early in vertebrate evolution often through the differential retention of the regulatory gene but loss of the bystander gene's exonic sequences. Despite the large evolutionary scale, the presence of duplicated highly conserved noncoding regions provided unambiguous proof for this scenario for multiple ancient GRBs. Remarkably, the dismantling of ancient GRB duplicates has contributed to the creation of large gene deserts associated with regulatory genes in vertebrates, providing a potentially widespread mechanism for the origin of these enigmatic genomic traits.
英文关键词	gene deserts whole-genome duplications origin of vertebrates genomic regulatory block
类型	Article
语种	英语
开放获取类型	Green Published, Green Submitted, hybrid
收录类别	SCI-E
WOS记录号	WOS:000593115800006
WOS关键词	AMPHIOXUS GENOME ; EVOLUTION ; CONSERVATION ; MICROSYNTENY ; ZEBRAFISH ; ORIGIN
WOS类目	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS研究方向	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327684
作者单位	[Touceda-Suarez, Maria; Kita, Elizabeth M.; Irimia, Manuel] Barcelona Inst Sci & Technol, Ctr Genom Regulat CRG, Barcelona, Spain; [Acemel, Rafael D.; Firbas, Panos N.; Magri, Marta S.; Naranjo, Silvia; Tena, Juan J.; Gomez-Skarmeta, Jose Luis; Maeso, Ignacio] Univ Pablo Olavide Junta Andalucia, Ctr Andaluz Biol Desarrollo CABD, CSIC, Seville, Spain; [Irimia, Manuel] Univ Pompeu Fabra UPF, Barcelona, Spain; [Irimia, Manuel] ICREA, Barcelona, Spain
推荐引用方式 GB/T 7714	Touceda-Suarez, Maria,Kita, Elizabeth M.,Acemel, Rafael D.,et al. Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications[J],2020,37(10):2857-2864.
APA	Touceda-Suarez, Maria.,Kita, Elizabeth M..,Acemel, Rafael D..,Firbas, Panos N..,Magri, Marta S..,...&Irimia, Manuel.(2020).Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications.MOLECULAR BIOLOGY AND EVOLUTION,37(10),2857-2864.
MLA	Touceda-Suarez, Maria,et al."Ancient Genomic Regulatory Blocks Are a Source for Regulatory Gene Deserts in Vertebrates after Whole-Genome Duplications".MOLECULAR BIOLOGY AND EVOLUTION 37.10(2020):2857-2864.