干旱区生态环境知识资源中心(Arid): Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta

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DOI	10.1016/j.bioorg.2020.104261
	Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta
	Zheng, Xiaofeng; Kadir, Abdukriem; Zheng, Guijuan; Jin, Pengfei; Qin, Dongmei; Maiwulanjiang, Maitinuer; Aisa, Haji Akber; Yao, Guangmin
通讯作者	Yao, GM
来源期刊	BIOORGANIC CHEMISTRY
ISSN	0045-2068
EISSN	1090-2120
出版年	2020
卷号	104
英文摘要	A total of twenty abietane quinone diterpenoids including ten new ones (1-10) were isolated from the roots extract of Salvia deserta. Their chemical structures were delineated by extensive spectrometric and spectroscopic techniques including HRESIMS, NMR, UV, IR, and single-crystal X-ray diffraction analysis, calculated C-13 NMR-DP4+ analysis, calculated ECD, and Mo-2(OAc)(4)-induced ECD. The absolute configurations of salvidesertone A (1), 8 alpha,9 alpha-epoxy-6-deoxycoleon U (18), and 7,20-epoxyroyleanone (19) were determined by single-crystal X-ray diffraction analysis. Salvidesertone A (1) represents the first example of a 9-hydroxyabieta-7(8)-ene quinone diterpenoid. This is the first report of the crystal structures of 8 alpha,9 alpha-epoxy-6-deoxycoleon U (18) and 7,20-epoxyroyleanone (19). Abietane quinone diterpenoids 1, 2, and 4-20 were evaluated for their antiproliferative activities against five cancer cell lines A-549, SMMC-7721, SW480, MCF-7, and HL-60 and a normal epithelial cell line BEAS-2B in vitro. Salvidesertones E (8) and F (9) selectively inhibited the proliferation of A-549, SMMC-7721, and SW480 cancer cell lines. Importantly, salvidesertones E (8) and F (9), horminone (13), taxoquinone (14), 7 alpha-O-methylhorminone (15), and 8 alpha,9 alpha-epoxy-6-deoxycoleon U (18) showed more potent antiproliferative effects against A-549 than the positive control cis-platin. A preliminary structure-activity relationship for the antiproliferative effects of abietane quinone diterpenoids 1-20 was discussed.
英文关键词	Salvia deserta Schang (Lamiaceae) Abietane quinone diterpenoids Calculated C-13 NMR-DP4+analysis Mo-2(OAc)(4)-induced ECD Antiproliferative activity
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000592527300002
WOS关键词	CARBON SKELETON ; GRAYANANE DITERPENOIDS ; CYTOTOXIC ACTIVITY ; LEAVES ; CONSTITUENTS ; DERIVATIVES ; LABIATAE ; PLANTS
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Organic
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327650
作者单位	[Zheng, Xiaofeng; Kadir, Abdukriem; Zheng, Guijuan; Jin, Pengfei; Yao, Guangmin] Huazhong Univ Sci & Technol, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China; [Kadir, Abdukriem; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China; [Qin, Dongmei] Shihezi Univ, Key Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Sch Pharm, Shihezi 832000, Xinjiang, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Xiaofeng,Kadir, Abdukriem,Zheng, Guijuan,et al. Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta[J],2020,104.
APA	Zheng, Xiaofeng.,Kadir, Abdukriem.,Zheng, Guijuan.,Jin, Pengfei.,Qin, Dongmei.,...&Yao, Guangmin.(2020).Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta.BIOORGANIC CHEMISTRY,104.
MLA	Zheng, Xiaofeng,et al."Antiproliferative abietane quinone diterpenoids from the roots of Salvia deserta".BIOORGANIC CHEMISTRY 104(2020).