干旱区生态环境知识资源中心(Arid): Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking

Arid

DOI	10.3390/molecules25194446
	Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking
	Wang, Ting; Lu, Qinpei; Sun, Chenghang; Lukianov, Dmitrii; Osterman, Ilya Andreevich; Sergiev, Petr Vladimirovich; Dontsova, Olga Anatolievna; Hu, Xinxin; You, Xuefu; Liu, Shaowei; Wu, Gang
通讯作者	Liu, SW ; Wu, G
来源期刊	MOLECULES
EISSN	1420-3049
出版年	2020
卷号	25 期号:19
英文摘要	To combat escalating levels of antibiotic resistance, novel strategies are developed to address the everlasting demand for new antibiotics. This study aimed at investigating amicoumacin antibiotics from the desert-derived Bacillus subtilis PJS by using the modern MS/MS-based molecular networking approach. Two new amicoumacins, namely hetiamacin E (1) and hetiamacin F (2), were finally isolated. The planar structures were determined by analysis of extensive NMR spectroscopic and HR-ESI-MS data, and the absolute configurations were concluded by analysis of the CD spectrum. Hetiamacin E (1) showed strong antibacterial activities against methicillin-sensitive and resistant Staphylococcus epidermidis at 2-4 mu g/mL, and methicillin-sensitive and resistant Staphylococcus aureus at 8-16 mu g/mL. Hetiamacin F (2) exhibited moderate antibacterial activities against Staphylococcus sp. at 32 mu g/mL. Both compounds were inhibitors of protein biosynthesis demonstrated by a double fluorescent protein reporter system.
英文关键词	Bacillus subtilis PJS amicoumacins antibacterial activity methicillin-resistant Staphylococcus aureus (MRSA) inhibitors of protein biosynthesis
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000586421300001
WOS关键词	MASS-SPECTROMETRY ; ISOCOUMARIN ; METABOLITES ; DISCOVERY
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327348
作者单位	[Wang, Ting; Lu, Qinpei; Sun, Chenghang; Hu, Xinxin; You, Xuefu; Liu, Shaowei; Wu, Gang] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China; [Wang, Ting; Lu, Qinpei; Sun, Chenghang; Hu, Xinxin; You, Xuefu; Liu, Shaowei; Wu, Gang] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing Key Lab Antimicrobial Agents, Beijing 100050, Peoples R China; [Lukianov, Dmitrii; Osterman, Ilya Andreevich; Sergiev, Petr Vladimirovich; Dontsova, Olga Anatolievna] Skolkovo Inst Sci & Technol, Ctr Life Sci, Moscow 143025, Russia; [Osterman, Ilya Andreevich; Sergiev, Petr Vladimirovich; Dontsova, Olga Anatolievna] Lomonosov Moscow State Univ, Dept Chem, Moscow 119992, Russia; [Dontsova, Olga Anatolievna] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 119992, Russia
推荐引用方式 GB/T 7714	Wang, Ting,Lu, Qinpei,Sun, Chenghang,et al. Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking[J],2020,25(19).
APA	Wang, Ting.,Lu, Qinpei.,Sun, Chenghang.,Lukianov, Dmitrii.,Osterman, Ilya Andreevich.,...&Wu, Gang.(2020).Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking.MOLECULES,25(19).
MLA	Wang, Ting,et al."Hetiamacin E and F, New Amicoumacin Antibiotics from Bacillus subtilis PJS Using MS/MS-Based Molecular Networking".MOLECULES 25.19(2020).