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DOI	10.36721/PJPS.2020.33.5.SP.2461-2469.1
	Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant
	Younus, Muhammad; Hasan, Muhammad Mohtasheemul; Khalil, Sadia; Saddiq, Bushra; Ahmad, Khalil; Jamil, Qazi Adnan; Shirazi, Jafir Hussain; Hanif, Muhammad; Sajid-ur-Rehman, Muhammad; Khan, Kashif-ur-Rehman; Aziz, Muhammad Imran
通讯作者	Younus, M
来源期刊	PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
ISSN	1011-601X
出版年	2020
卷号	33 期号:5 页码:2461-2469
英文摘要	Euphorbia nivulia a locally occurring plant species possesses antiseptic, analgesic and anti-inflammatory properties and is ethnopharmacologically used in various ailments like skin, ear disorders, boils, and woiin infestation. Preliminary phytochemical screening showed presence of flavonoids, polyphenolics, glycosides, alkaloids, tannins and triterpenoids in (70% aqueous-ethanolic) Euphorbia nivulia crude extract (En cr) and its four fractions, i.e., hexane fraction (En hex), butanol fraction (En bt), chloroform fraction (En ch), and aqueous fraction (En aq). In current study, Agar well diffusion and time-kill kinetic assays were perfouned for antimicrobial activity. 300 mg/ml concentration showed maximum inhibitory zone. Highest zone of inhibition (15.5mm) was demonstrated by En ch fraction against Proteus mirabilis. Staphyllococcus aureus was the most sensitive bacteria against whom all fractions except En aq fraction were active. Maximum MIC (15.3 mg/ml) was shown by En ch fraction against Proteus mirabilis. Similarly, En ch fraction showed (15.1 mg/ml) remarkable MIC against Candida albicans. Significant higher antibacterial and antifungal activity was revealed in high concentration. Time-kill kinetics studies revealed bacteriostatic action. Noteworthy antimicrobial activity may be due to bioactive compounds of extract which may be a potential antibacterial and antifungal agent.
英文关键词	Euphorbia nivulia bio-active compounds time-kill kinetics antimicrobial activity
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000585084800014
WOS关键词	ANTIBACTERIAL ACTIVITY ; ESSENTIAL OILS ; FLAVONOIDS ; PRODUCTS ; EXTRACTS
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/327263
作者单位	[Younus, Muhammad; Hasan, Muhammad Mohtasheemul] Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmacognosy, Karachi, Pakistan; [Khalil, Sadia] Fed Urdu Univ Sci & Technol, Dept Microbiol, Karachi, Pakistan; [Saddiq, Bushra] Islamia Univ Bahawalpur, Dept Entomol, Bahawalpur, Pakistan; [Ahmad, Khalil] Islamia Univ Bahawalpur, Univ Coll Convent Med, Bahawalpur, Pakistan; [Jamil, Qazi Adnan; Shirazi, Jafir Hussain] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur, Pakistan; [Hanif, Muhammad] Benazir Bhutto Shaheed Univ, Dept Pharm, Karachi, Pakistan; [Younus, Muhammad; Sajid-ur-Rehman, Muhammad] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmacognosy, Bahawalpur, Pakistan; [Khan, Kashif-ur-Rehman] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut Chem, Bahawalpur, Pakistan; [Aziz, Muhammad Imran] Gomal Univ, Fac Pharm, Dept Pharmacognosy, Dera Ismail Khan, Pakistan
推荐引用方式 GB/T 7714	Younus, Muhammad,Hasan, Muhammad Mohtasheemul,Khalil, Sadia,et al. Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant[J],2020,33(5):2461-2469.
APA	Younus, Muhammad.,Hasan, Muhammad Mohtasheemul.,Khalil, Sadia.,Saddiq, Bushra.,Ahmad, Khalil.,...&Aziz, Muhammad Imran.(2020).Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant.PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,33(5),2461-2469.
MLA	Younus, Muhammad,et al."Phytochemical, antimicrobial and time-kill kinetics potentials of Euphorbia nivulia Buch.-Ham.: A Cholistan desert medicinal plant".PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 33.5(2020):2461-2469.