干旱区生态环境知识资源中心(Arid): Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets

Arid

DOI	10.3389/fonc.2020.544610
	Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets
	Tang, Chaozhi; Ma, Jiakang; Liu, Xiuli; Liu, Zhengchun
通讯作者	Liu, ZC
来源期刊	FRONTIERS IN ONCOLOGY
ISSN	2234-943X
出版年	2020
卷号	10
英文摘要	Molecular classification of bladder cancer is becoming increasingly important for its clinical management. And, the current classifications are primarily based on gene expression profiles. We identified four immunotypes of bladder cancer (referred to as C1-C4) based on gene expression profiles performed by immune-related gene sets in three independent data sets, and proved that this classification is effective and reproducible. We found that C2 is an immune-infiltrating type and C4 is an immune desert type. These types are characterized by the up- and downregulation of genes encoding numerous immune checkpoint proteins and HLA and regulating human immune cell subgroups. The survival rate was better for the C2 subtype than for other subtypes. We believe that this can be explained by the antitumor effects of CD4 memory T cells and CD8 T cells as well as their ability to circumvent M0 macrophage antitumor immunity. In addition, C2 was most sensitive to not only anti-PD-1 immunosuppressive therapy, but also conventional chemotherapeutics such as gemcitabine and bleomycin. The C4 subtype was most sensitive to the chemotherapy drugs cisplatin and doxorubicin. This theoretical framework may guide the personalized treatment of bladder cancer in the future. It is worth noting that the C2 immune infiltration type positively correlates with a variety of stromal components, such as enrichment of endothelial cells and fibroblasts, epithelial-mesenchymal transition, and angiogenesis, together with enrichment of seven kinds of stem cells. We further identified tumor-related JAK-STAT and other signaling pathways in the C2 subtype, along with important mutations in the proteins involved in these pathways, revealing the complex mechanism underlying tumor immune escape. Our results, and particularly the identification of hub genes specific to the C2 and C4 subtypes, provide a reference for the development of immunotherapeutic agents against bladder cancer.
英文关键词	immunotype bladder cancer immune cell gene set enrichment analysis prognosis
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000579476400001
WOS关键词	IMMUNOTHERAPY ; ADHESION ; TUMORS
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326863
作者单位	[Tang, Chaozhi] China Med Univ, Dept Urol, Affiliated Hosp 1, Shenyang, Peoples R China; [Ma, Jiakang] Zhengzhou Univ, Dept Oncol, Affiliated Hosp 2, Zhengzhou, Peoples R China; [Liu, Xiuli] Guilin Med Univ, Affiliated Hosp, Dept Oncol, Guilin, Peoples R China; [Liu, Zhengchun] Guilin Med Univ, Dept Radiat Oncol, Affiliated Hosp, Guilin, Peoples R China
推荐引用方式 GB/T 7714	Tang, Chaozhi,Ma, Jiakang,Liu, Xiuli,et al. Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets[J],2020,10.
APA	Tang, Chaozhi,Ma, Jiakang,Liu, Xiuli,&Liu, Zhengchun.(2020).Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets.FRONTIERS IN ONCOLOGY,10.
MLA	Tang, Chaozhi,et al."Identification of Four Immune Subtypes in Bladder Cancer Based on Immune Gene Sets".FRONTIERS IN ONCOLOGY 10(2020).