干旱区生态环境知识资源中心(Arid): Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta

Arid

DOI	10.1039/d0qo00735h
	Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta
	Zheng, Guijuan; Kadir, Abdukriem; Zheng, Xiaofeng; Jin, Pengfei; Liu, Junjun; Maiwulanjiang, Maitinuer; Yao, Guangmin; Aisa, Haji Akber
通讯作者	Yao, GM ; Aisa, HA
来源期刊	ORGANIC CHEMISTRY FRONTIERS
ISSN	2052-4129
出版年	2020
卷号	7 期号:20 页码:3137-3145
英文摘要	Two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran2,1'-cyclohexane] motif, spirodesertols A (1) and B (2), four new icetexane diterpenoids, salviadenones A-D (3-6), together with their biogenetic precursor, 20-deoxocarnosol (7), were isolated from the root extract of Salvia deserta. Their structures were elucidated by spectroscopic analysis, quantum chemical calculations including the 13C chemical shift calculations with DP4+ probability analysis and electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. The plausible biogenetic pathways for 1-6 were proposed. Compounds 1-7 were evaluated for their cytotoxicity against five cancer cell lines. Spirodesertol A (1) showed more potent cytotoxicity against the A-549, SMMC-7721, and MCF-7 cancer cell lines than the positive control, cisplatin.
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000579143200022
WOS关键词	ABIETANE DITERPENOIDS ; CONSTITUENTS ; ICETEXANE ; ROOTS ; BUDS
WOS类目	Chemistry, Organic
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326832
作者单位	[Zheng, Guijuan; Kadir, Abdukriem; Maiwulanjiang, Maitinuer; Yao, Guangmin; Aisa, Haji Akber] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Xinjiang, Peoples R China; [Zheng, Guijuan; Zheng, Xiaofeng; Jin, Pengfei; Liu, Junjun; Yao, Guangmin] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Guijuan,Kadir, Abdukriem,Zheng, Xiaofeng,et al. Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta[J],2020,7(20):3137-3145.
APA	Zheng, Guijuan.,Kadir, Abdukriem.,Zheng, Xiaofeng.,Jin, Pengfei.,Liu, Junjun.,...&Aisa, Haji Akber.(2020).Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta.ORGANIC CHEMISTRY FRONTIERS,7(20),3137-3145.
MLA	Zheng, Guijuan,et al."Spirodesertols A and B, two highly modified spirocyclic diterpenoids with an unprecedented 6-isopropyl-3H-spiro[benzofuran-2,1 ' cyclohexane] motif from Salvia deserta".ORGANIC CHEMISTRY FRONTIERS 7.20(2020):3137-3145.