干旱区生态环境知识资源中心(Arid): Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol

Arid

DOI	10.1186/s12877-020-01799-y
	Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol
	Hoque, Laboni; Dewolf, Ryan; Meyers, David; White, Daniel K.; Mazor, Kathleen M.; Stefan, Mihaela; Crawford, Sybil; Alavi, Karim; Yates, Jennifer; Maxfield, Mark; Lou, Feiran; Uy, Karl; Walz, Matthias; Kapoor, Alok
通讯作者	Kapoor, A
来源期刊	BMC GERIATRICS
EISSN	1471-2318
出版年	2020
卷号	20 期号:1
英文摘要	BackgroundFrail older surgical patients face more than a two-fold increase in postoperative complications, including myocardial infarction, deep vein thrombosis, pulmonary embolism, pneumonia, ileus, and others. Many of these complications occur because of postoperative loss of stamina and poor mobility. Preoperative exercise may better prepare these vulnerable patients for surgery. We present the protocol for our ongoing randomized trial to assess the impact of a preoperative walking intervention with remote coaching and pedometer on outcomes of stamina (six-minute walk distance- 6MWD) and mobility (postoperative steps) in older adults with frailty traits.MethodsWe will be conducting a randomized clinical trial with a total of 120 patients permitting up to a 33% rate of attrition, to reach a final sample size of 80 (with 40 patients for each study arm). We will include patients who are age 60 or higher, score 4 or greater on the Edmonton Frailty Scale assessment, and will be undergoing a surgical operation that requires a 2 or more night hospital stay to be eligible for our trial. Using block randomization stratified on baseline 6MWD, we will assign patients to wear a pedometer. At the end of three baseline days, an athletic trainer (AT) will provide a daily step count goal reflecting a 10-20% increase from baseline. Subsequently, the AT will call weekly to further titrate the goal or calls more frequently if the patient is not meeting the prescribed goal. Controls will receive general walking advice. Our main outcome is change in 6MWD on postoperative day (POD) 2/3 vs. baseline. We will also collect 6MWD approximately 4weeks after surgery and daily in-hospital steps.ConclusionIf changes in a 6MWD and step counts are significantly higher for the intervention group, we believe this will confirm our hypothesis that the intervention leads to decreased loss of stamina and mobility. Once confirmed, we anticipate expanding to multiple centers to assess the interventional impact on clinical endpoints.Trial registrationThe randomized clinical trial was registered on clinicaltrials.gov under the identifier NCT03892187 on March 27, 2019.
英文关键词	Frailty Surgery Prehabilitation Stamina
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000578577200004
WOS关键词	REPLACEMENT ; EXERCISE ; VETERANS ; HEALTH
WOS类目	Geriatrics & Gerontology ; Gerontology
WOS研究方向	Geriatrics & Gerontology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326803
作者单位	[Hoque, Laboni; Dewolf, Ryan; Mazor, Kathleen M.; Stefan, Mihaela; Crawford, Sybil; Alavi, Karim; Yates, Jennifer; Maxfield, Mark; Lou, Feiran; Uy, Karl; Walz, Matthias; Kapoor, Alok] Univ Massachusetts, Med Sch, 365 Plantat St, Worcester, MA 01605 USA; [Meyers, David; Alavi, Karim; Yates, Jennifer; Maxfield, Mark; Lou, Feiran; Uy, Karl; Walz, Matthias; Kapoor, Alok] Univ Massachusetts, Mem Hlth Care, Worcester, MA 01605 USA; [White, Daniel K.] Univ Delaware, Newark, DE USA; [Mazor, Kathleen M.; Kapoor, Alok] Meyers Primary Care Inst, Joint Endeavor Univ Massachusetts Med Sch Reliant, Worcester, MA 01605 USA; [Stefan, Mihaela] Baystate Med Ctr, Springfield, MA USA
推荐引用方式 GB/T 7714	Hoque, Laboni,Dewolf, Ryan,Meyers, David,et al. Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol[J],2020,20(1).
APA	Hoque, Laboni.,Dewolf, Ryan.,Meyers, David.,White, Daniel K..,Mazor, Kathleen M..,...&Kapoor, Alok.(2020).Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol.BMC GERIATRICS,20(1).
MLA	Hoque, Laboni,et al."Improving stamina and mobility with preop walking in surgical patients with frailty traits -OASIS IV: randomized clinical trial study protocol".BMC GERIATRICS 20.1(2020).