干旱区生态环境知识资源中心(Arid): Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis

Arid

DOI	10.1016/j.euroneuro.2020.08.002
	Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis
	Fusar-Poli, Paolo; Spencer, Thomas; De Micheli, Andrea; Curzi, Victoria; Nandha, Sunil; McGuire, Philip
通讯作者	Fusar-Poli, P
来源期刊	EUROPEAN NEUROPSYCHOPHARMACOLOGY
ISSN	0924-977X
EISSN	1873-7862
出版年	2020
卷号	39 页码:111-122
英文摘要	This study aims to describe twenty years of early detection, prognosis and preventive care in the Outreach and Support In South-London (OASIS) mental health service for individuals at Clinical High risk of psychosis (CHR-P). The study presents a comprehensive analysis of the 20012020 activity of the OASIS team encompassing core domains: (i) service characteristics, (ii) detection, (iii) prognosis, (iv) treatment and (v) clinical research. The analyses employed descriptive statistics, population-level data, the epidemiological incidence of psychosis, Kaplan Meier failure functions and Greenwood 95% CIs and Electronic Health Records. OASIS is part of the South London and Maudsley (SLaM) NHS trust, the largest European mental health provider, serving a total urban population of 1,358,646 individuals (population aged 16-35: 454,525). Incidence of psychosis in OASIS's catchment area ranges from 58.3 to 71.9 cases per 100,000 person-years, and it is higher than the national average of 41.5 cases per 100,000 personyear. OASIS is a standalone, NHS-funded, multidisciplinary (team leader, consultant and junior psychiatrists, clinical psychologists, mental health professionals), transitional (for those aged 14-35 years) community mental health service with a yearly caseload of 140 CHR-P individuals. OASIS regularly delivers a comprehensive service promotion outreach to several local community organisations. Referrals to OASIS (2366) are made by numerous agencies; about one-third of the referrals eventually met CHR-P criteria. Overall, 600 CHR-P individuals (55.33% males, mean age 22.63 years, white ethnicity 46.44%) have been under the care of the OASIS service: 80.43% met attenuated psychotic symptoms, 18.06% brief and limited intermittent psychotic symptoms and 1.51% genetic risk and deterioration CHR-P criteria. All CHR-P individuals were offered cognitive behavioural therapy and psychosocial support; medications were used depending on individual needs. The cumulative risk of psychosis at ten years was 0.365 (95%CI 0.302-0.437). At six years follow-up, across two-third of individuals non-transitioning to psychosis, 79.24% still displayed some mental health problem, and only 20.75% achieved a complete clinical remission. Research conducted at OASIS encompassed clinical, prognostic, neurobiological and interventional studies and leveraged local, national and international infrastructures; over the past ten years, OASIS-related research attracted about pound 50 million of grant income, with 5,922 citations in the international databases. Future developments may include broadening OASIS to prevent other serious mental disorders beyond psychosis and fostering translational risk prediction and interventional research. With a twenty-years activity, OASIS' cutting-edge quality of preventive care, combined with translational research innovations, consolidated the service as a leading reference model for evidence-based prevention of psychosis worldwide. (C) 2020 The Authors. Published by Elsevier B.V.
英文关键词	Psychosis Schizophrenia Prevention ARMS UHR CHR
类型	Article
语种	英语
开放获取类型	Green Published, hybrid
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000577531000009
WOS关键词	ULTRA-HIGH RISK ; CLINICAL HIGH-RISK ; INDIVIDUALS ; STATE ; METAANALYSIS ; INTERVENTIONS ; PREDICTION ; DISORDERS ; VALIDITY ; OUTCOMES
WOS类目	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326766
作者单位	[Fusar-Poli, Paolo; De Micheli, Andrea] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England; [Fusar-Poli, Paolo; Spencer, Thomas; De Micheli, Andrea; Curzi, Victoria; Nandha, Sunil] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England; [Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy; [Spencer, Thomas; McGuire, Philip] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
推荐引用方式 GB/T 7714	Fusar-Poli, Paolo,Spencer, Thomas,De Micheli, Andrea,et al. Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis[J]. University of London,2020,39:111-122.
APA	Fusar-Poli, Paolo,Spencer, Thomas,De Micheli, Andrea,Curzi, Victoria,Nandha, Sunil,&McGuire, Philip.(2020).Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis.EUROPEAN NEUROPSYCHOPHARMACOLOGY,39,111-122.
MLA	Fusar-Poli, Paolo,et al."Outreach and support in South-London (OASIS) 2001-2020: Twenty years of early detection, prognosis and preventive care for young people at risk of psychosis".EUROPEAN NEUROPSYCHOPHARMACOLOGY 39(2020):111-122.