干旱区生态环境知识资源中心(Arid): Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules

Arid

DOI	10.1038/s41598-020-72598-z
	Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules
	Rossi, Marta; Ott, Swidbert R.; Niven, Jeremy E.
通讯作者	Rossi, M ; Niven, JE
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2020
卷号	10 期号:1
英文摘要	Malpighian tubules, analogous to vertebrate nephrons, play a key role in insect osmoregulation and detoxification. Tubules can become infected with a protozoan, Malpighamoeba, which damages their epithelial cells, potentially compromising their function. Here we used a modified Ramsay assay to quantify the impact of Malpighamoeba infection on fluid secretion and P-glycoprotein-dependent detoxification by desert locust Malpighian tubules. Infected tubules have a greater surface area and a higher fluid secretion rate than uninfected tubules. Infection also impairs P-glycoprotein-dependent detoxification by reducing the net rhodamine extrusion per surface area. However, due to the increased surface area and fluid secretion rate, infected tubules have similar total net extrusion per tubule to uninfected tubules. Increased fluid secretion rate of infected tubules likely exposes locusts to greater water stress and increased energy costs. Coupled with reduced efficiency of P-glycoprotein detoxification per surface area, Malpighamoeba infection is likely to reduce insect survival in natural environments.
类型	Article
语种	英语
开放获取类型	Green Published, Green Accepted, Green Submitted, gold
收录类别	SCI-E
WOS记录号	WOS:000577129100016
WOS关键词	SCHISTOCERCA GREGARIA FORSKAL ; DESERT LOCUST ; TRANSEPITHELIAL TRANSPORT ; RECTAL ABSORPTION ; ACTIVE-TRANSPORT ; ORGANIC CATION ; PHYSIOLOGY ; ULTRASTRUCTURE ; INSECTICIDE ; GLUTATHIONE
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326742
作者单位	[Rossi, Marta; Niven, Jeremy E.] Univ Sussex, Sch Life Sci, Brighton BN1 9QG, E Sussex, England; [Ott, Swidbert R.] Univ Leicester, Dept Neurosci Psychol & Behav, Adrian Bldg,Univ Rd, Leicester LE1 7RH, Leics, England; [Niven, Jeremy E.] Univ Sussex, Ctr Computat Neurosci & Robot, Brighton BN1 9QG, E Sussex, England
推荐引用方式 GB/T 7714	Rossi, Marta,Ott, Swidbert R.,Niven, Jeremy E.. Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules[J],2020,10(1).
APA	Rossi, Marta,Ott, Swidbert R.,&Niven, Jeremy E..(2020).Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules.SCIENTIFIC REPORTS,10(1).
MLA	Rossi, Marta,et al."Malpighamoeba infection compromises fluid secretion and P-glycoprotein detoxification in Malpighian tubules".SCIENTIFIC REPORTS 10.1(2020).