干旱区生态环境知识资源中心(Arid): Multitracer model for staging cortical amyloid deposition using PET imaging

Arid

DOI	10.1212/WNL.0000000000010256
	Multitracer model for staging cortical amyloid deposition using PET imaging
	Collij, Lyduine E.; Heeman, Fiona; Salvado, Gemma; Ingala, Silvia; Altomare, Daniele; de Wilde, Arno; Konijnenberg, Elles; van Buchem, Marieke; Yaqub, Maqsood; Markiewicz, Pawel; Golla, Sandeep S., V; Wottschel, Viktor; Wink, Alle Meije; Visser, Pieter Jelle; Teunissen, Charlotte E.; Lammertsma, Adriaan A.; Scheltens, Philip; van der Flier, Wiesje M.; Boellaard, Ronald; van Berckel, Bart N. M.; Molinuevo, Jose Luis; Gispert, Juan Domingo; Schmidt, Mark E.; Barkhof, Frederik; Alves, Isadora Lopes
通讯作者	Alves, IL
来源期刊	NEUROLOGY
ISSN	0028-3878
EISSN	1526-632X
出版年	2020
卷号	95 期号:11 页码:E1538-E1553
英文摘要	Objective To develop and evaluate a model for staging cortical amyloid deposition using PET with high generalizability. Methods Three thousand twenty-seven individuals (1,763 cognitively unimpaired [CU], 658 impaired, 467 with Alzheimer disease [AD] dementia, 111 with non-AD dementia, and 28 with missing diagnosis) from 6 cohorts (European Medical Information Framework for AD, Alzheimer's and Family, Alzheimer's Biomarkers in Daily Practice, Amsterdam Dementia Cohort, Open Access Series of Imaging Studies [OASIS]-3, Alzheimer's Disease Neuroimaging Initiative [ADNI]) who underwent amyloid PET were retrospectively included; 1,049 individuals had follow-up scans. With application of dataset-specific cutoffs to global standard uptake value ratio (SUVr) values from 27 regions, single-tracer and pooled multitracer regional rankings were constructed from the frequency of abnormality across 400 CU individuals (100 per tracer). The pooled multitracer ranking was used to create a staging model consisting of 4 clusters of regions because it displayed a high and consistent correlation with each single-tracer ranking. Relationships between amyloid stage, clinical variables, and longitudinal cognitive decline were investigated. Results SUVr abnormality was most frequently observed in cingulate, followed by orbitofrontal, precuneal, and insular cortices and then the associative, temporal, and occipital regions. Abnormal amyloid levels based on binary global SUVr classification were observed in 1.0%, 5.5%, 17.9%, 90.0%, and 100.0% of individuals in stage 0 to 4, respectively. Baseline stage predicted decline in Mini-Mental State Examination (MMSE) score (ADNI: n = 867,F= 67.37,p< 0.001; OASIS: n = 475,F= 9.12,p< 0.001) and faster progression toward an MMSE score <= 25 (ADNI: n = 787, hazard ratio [HR](stage1)2.00, HR(stage2)3.53, HR(stage3)4.55, HR(stage4)9.91,p< 0.001; OASIS: n = 469, HR(stage4)4.80,p< 0.001). Conclusion The pooled multitracer staging model successfully classified the level of amyloid burden in >3,000 individuals across cohorts and radiotracers and detects preglobal amyloid burden and distinct risk profiles of cognitive decline within globally amyloid-positive individuals.
类型	Article
语种	英语
开放获取类型	hybrid, Green Published
收录类别	SCI-E
WOS记录号	WOS:000576025700021
WOS关键词	ALZHEIMERS-DISEASE ; PATHOLOGY ; DEMENTIA ; BURDEN ; PHASES
WOS类目	Clinical Neurology
WOS研究方向	Neurosciences & Neurology
来源机构	University of London
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326666
作者单位	[Collij, Lyduine E.; Heeman, Fiona; Ingala, Silvia; Yaqub, Maqsood; Golla, Sandeep S., V; Wottschel, Viktor; Wink, Alle Meije; Lammertsma, Adriaan A.; Boellaard, Ronald; van Berckel, Bart N. M.; Barkhof, Frederik; Alves, Isadora Lopes] Vrije Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Amsterdam, Netherlands; [Teunissen, Charlotte E.] Vrije Univ Amsterdam, Neurochem Lab, Amsterdam UMC, Amsterdam, Netherlands; [Altomare, Daniele; de Wilde, Arno; Konijnenberg, Elles; van Buchem, Marieke; Visser, Pieter Jelle; Scheltens, Philip; van der Flier, Wiesje M.] Vrije Univ Amsterdam, Alzheimer Ctr, Amsterdam UMC, Amsterdam, Netherlands; [Altomare, Daniele; de Wilde, Arno; Konijnenberg, Elles; van Buchem, Marieke; Visser, Pieter Jelle; Scheltens, Philip; van der Flier, Wiesje M.] Vrije Univ Amsterdam, Dept Neurol, Amsterdam UMC, Amsterdam, Netherlands; [Salvado, Gemma; Molinuevo, Jose Luis; Gispert, Juan Domingo] Pasqua Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain; [Gispert, Juan Doming...
推荐引用方式 GB/T 7714	Collij, Lyduine E.,Heeman, Fiona,Salvado, Gemma,et al. Multitracer model for staging cortical amyloid deposition using PET imaging[J]. University of London,2020,95(11):E1538-E1553.
APA	Collij, Lyduine E..,Heeman, Fiona.,Salvado, Gemma.,Ingala, Silvia.,Altomare, Daniele.,...&Alves, Isadora Lopes.(2020).Multitracer model for staging cortical amyloid deposition using PET imaging.NEUROLOGY,95(11),E1538-E1553.
MLA	Collij, Lyduine E.,et al."Multitracer model for staging cortical amyloid deposition using PET imaging".NEUROLOGY 95.11(2020):E1538-E1553.