干旱区生态环境知识资源中心(Arid): Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses

Arid

DOI	10.1016/j.jevs.2020.103193
	Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses
	Dedar, Ramesh Kumar; Kumar, Naveen; Narnaware, Shirish D.; Tripathi, Bhupendra Nath
通讯作者	Dedar, RK
来源期刊	JOURNAL OF EQUINE VETERINARY SCIENCE
ISSN	0737-0806
EISSN	1542-7412
出版年	2020
卷号	93
英文摘要	Wound healing in horses is complicated by the excessive growth of granulation tissue, commonly known as proud flesh and is similar to keloids in human beings. At present, there is no satisfactory treatment for proud flesh in horses. In this study, we, for the first time, demonstrated that leaf extract of Aerva javanica suppresses excessive growth of granulation tissue in horses. Many plant flavonoids are claimed to have antiproliferative properties. Kaempferol is a natural flavonoid containing 3-hydroxy flavone backbone found in many plants in its aglycone form and attached with various sugars. Ecdysteroids are steroidal analogs of invertebrate steroidal hormones found in plants. Both flavonoids and ecdysteroids accumulate more in plants during abiotic stress. We hypothesized that Aerva javanica may have high levels of ecdysteroids and kaempferols for surviving in stressful conditions of desert. Those kaempferols may suppress the growth of granulation tissue by their antiangiogenesis property. Ecdysteroids may control the larvae of habronema if associated with proud flesh. Extract was prepared using solvent-based fractionation and silica gel column flash chromatography. Application of the leaf extract in horses suppressed growth of granulation tissue along with restoration of normal skin function. Various purification steps and mass spectrometry were used to identify the active components in the study. (C) 2020 Elsevier Inc. All rights reserved.
英文关键词	Aerva javanica Excessive growth of granulation tissue Horse Kaempferol Keloid Proud flesh
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000574914200012
WOS关键词	EQUINE SKIN ; PATHOMECHANISMS ; EXPRESSION ; KELOIDS
WOS类目	Veterinary Sciences
WOS研究方向	Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326620
作者单位	[Dedar, Ramesh Kumar] ICAR Natl Res Ctr Equines, Vet Med, Reg Ctr, Equine Prod Campus Bikaner Rajasthan, Hisar, Haryana, India; [Kumar, Naveen] ICAR Natl Res Ctr Equines, Natl Ctr Vet Type Culture Hisar, Vet Microbiol, Hisar, Haryana, India; [Narnaware, Shirish D.] ICAR Natl Res Ctr Camel, Vet Pathol, Jorbeer Bikaner, Rajasthan, India; [Tripathi, Bhupendra Nath] ICAR Natl Res Ctr Equines, Hisar, Haryana, India
推荐引用方式 GB/T 7714	Dedar, Ramesh Kumar,Kumar, Naveen,Narnaware, Shirish D.,et al. Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses[J],2020,93.
APA	Dedar, Ramesh Kumar,Kumar, Naveen,Narnaware, Shirish D.,&Tripathi, Bhupendra Nath.(2020).Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses.JOURNAL OF EQUINE VETERINARY SCIENCE,93.
MLA	Dedar, Ramesh Kumar,et al."Leaf Extract of Aerva javanica Suppresses Excessive Growth of Granulation Tissue in Horses".JOURNAL OF EQUINE VETERINARY SCIENCE 93(2020).