干旱区生态环境知识资源中心(Arid): Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia

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DOI	10.1016/j.sjbs.2020.05.028
	Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia
	Alnuqaydan, Abdullah M.; Rah, Bilal
通讯作者	Alnuqaydan, AM ; Rah, B
来源期刊	SAUDI JOURNAL OF BIOLOGICAL SCIENCES
ISSN	1319-562X
EISSN	2213-7106
出版年	2020
卷号	27 期号:10 页码:2586-2592
英文摘要	Owing to extremely high salinity and harsh environmental conditions, T. articulata is one of the most abundant wild plants growing in the deserts of Saudi Arabia. Such plants may contain novel compounds to display promising biological activities. Here, in this study, we evaluate the biological activities of methanolic extracts of fresh leaves, dry leaves, stem, and roots of T. articulata. The antioxidant activity was determined by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and total phenolic and flavonoid content were determined using standard colorimetric methods. Whereas antimicrobial and ant-proliferative activities were determined by standard well-diffusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) methods, respectively. Our results demonstrate that all methanolic extracts of T. articulata showed antioxidant activity, however, the methanolic extract of dry leaves exhibits promising antioxidant effect with IC50 value 49.08 +/- 1.98, which was strongly supported by total phenolic (409.92 +/- 6.03 mg GAE/g DW) and flavonoid (177.71 mg QE/g DW) content. Although, antimicrobial activity was also exhibited by all the methanolic extracts, however, methanolic extract of dry leaves exhibits promising antimicrobial activity in Gram-positive bacteria Staphylococcus epidemidis. Furthermore, MTT assay revealed that all methanolic extracts exhibit antiproliferative activity in MCF-7 (breast cancer) and RKO (colorectal cancer) cells with IC50 values ranges from 219 +/- 5.112 mg/ml to 253 +/- 5.231 mg/ml and 220 +/- 4.330 mu g/ml to 325 +/- 6.213 mu g/ml, respectively. However, the most promising antiproliferative effect was displayed by methanolic extract of dry leaves with IC50 values 219 +/- 5.112 mu g/ml and 220 +/- 4.330 mu g/ml, respectively. In summary, these findings provide evidence that T. articulata has promising biological activities and can be used for many pharmaceutical activities in the future. (C) 2020 Published by Elsevier B.V. on behalf of King Saud University.
英文关键词	Tamarix articulata Antioxidant activity Antimicrobial activity Antiproliferative activity Cancer cell
类型	Article
语种	英语
开放获取类型	gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000570858800013
WOS关键词	ANTIMICROBIAL ACTIVITIES ; MEDICINAL-PLANTS ; ANTIOXIDANT ; EXTRACTS ; L. ; WITHAFERIN ; APOPTOSIS ; AUTOPHAGY
WOS类目	Biology
WOS研究方向	Life Sciences & Biomedicine - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326371
作者单位	[Alnuqaydan, Abdullah M.; Rah, Bilal] Qassim Univ, Coll Appl Med Sci, Dept Med Biotechnol, GPO POB 6666, Buraydah 51452, Saudi Arabia
推荐引用方式 GB/T 7714	Alnuqaydan, Abdullah M.,Rah, Bilal. Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia[J],2020,27(10):2586-2592.
APA	Alnuqaydan, Abdullah M.,&Rah, Bilal.(2020).Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia.SAUDI JOURNAL OF BIOLOGICAL SCIENCES,27(10),2586-2592.
MLA	Alnuqaydan, Abdullah M.,et al."Comparative assessment of biological activities of different parts of halophytic plant Tamarix articulata (T. articulata) growing in Saudi Arabia".SAUDI JOURNAL OF BIOLOGICAL SCIENCES 27.10(2020):2586-2592.