干旱区生态环境知识资源中心(Arid): Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients

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DOI	10.1038/s41598-020-71340-z
	Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients
	Son, Seung-Myoung; Woo, Chang Gok; Kim, Dae Hoon; Yun, Hyo Yung; Kim, Hongsik; Kim, Hee Kyung; Yang, Yaewon; Kwon, Jihyun; Kwon, Minsuk; Kim, Tae-Yong; Kim, Hyung-Don; Koh, June-Young; Park, Su-Hyung; Shin, Eui-Cheol; Han, Hye Sook
通讯作者	Han, HS
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2020
卷号	10 期号:1
英文摘要	This study compared the tumor immune microenvironments (TIMEs) of primary gastric cancer (PGC) and paired metastatic gastric cancer (MGC). CD4(+) and CD8(+) T-cell density and PD-L1 expression were evaluated by multiplex immunohistochemistry, DNA mismatch repair (MMR) by immunohistochemistry, and immune-related genes by RNA sequencing. Twenty-three patients who underwent surgical treatment for PGC and MGC were enrolled in this study. CD8(+) T-cell, PD-L1(+) cell, and PD-L1(+)CK(+) cell densities were significantly lower in MGC than PGC. PD-L1 positivity using a combined positive score (>= 1%) and deficient MMR were observed in 52.2% and 8.7% of PGC samples, respectively, whereas both occurred in only 4.3% of MGC samples. The most frequent TIME types were inflamed (34.8%) and adaptive immune resistance (34.8%) in PGC, and immune desert (65.2%) and immunological ignorance (73.9%) in MGC. In transcriptome analysis, the expression of the T-cell inflamed gene set and co-stimulatory gene module was down-regulated in MGC compared to PGC. The total CD8(+) T-cell density was an independent prognostic marker in both PGC and MGC (univariate P=0.002, multivariate P=0.006). Our result suggest that the TIME of metastatic tumors was less immunologically active compared to that of primary tumors in gastric cancer patients.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000570035500040
WOS关键词	INFILTRATING LYMPHOCYTES ; CELL ; NIVOLUMAB
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326339
作者单位	[Son, Seung-Myoung; Woo, Chang Gok] Chungbuk Natl Univ Hosp, Dept Pathol, Cheongju, South Korea; [Son, Seung-Myoung] Chungbuk Natl Univ, Dept Pathol, Coll Med, Cheongju, South Korea; [Kim, Dae Hoon; Yun, Hyo Yung] Chungbuk Natl Univ Hosp, Dept Surg, Cheongju, South Korea; [Yun, Hyo Yung] Chungbuk Natl Univ, Dept Surg, Coll Med, Cheongju, South Korea; [Kim, Hongsik; Kim, Hee Kyung; Yang, Yaewon; Kwon, Jihyun; Han, Hye Sook] Chungbuk Natl Univ Hosp, Dept Internal Med, Cheongju, South Korea; [Kwon, Jihyun; Han, Hye Sook] Chungbuk Natl Univ, Dept Internal Med, Coll Med, Chungdae Ro 1, Cheongju 28644, South Korea; [Kwon, Minsuk] Sungkyunkwan Univ, Div Hematol Oncol, Dept Internal Med, Samsung Med Ctr,Sch Med, Seoul, South Korea; [Kim, Tae-Yong] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; [Kim, Hyung-Don] Univ Ulsan, Dept Internal Med, Asan Med Ctr, Coll Med, Seoul, South Korea; [Koh, June-Young; Park, Su-Hyung; Shin, Eui-Cheol] Korea Adv Inst Sci & Technol, Grad Sch ...
推荐引用方式 GB/T 7714	Son, Seung-Myoung,Woo, Chang Gok,Kim, Dae Hoon,et al. Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients[J],2020,10(1).
APA	Son, Seung-Myoung.,Woo, Chang Gok.,Kim, Dae Hoon.,Yun, Hyo Yung.,Kim, Hongsik.,...&Han, Hye Sook.(2020).Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients.SCIENTIFIC REPORTS,10(1).
MLA	Son, Seung-Myoung,et al."Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients".SCIENTIFIC REPORTS 10.1(2020).