干旱区生态环境知识资源中心(Arid): A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke

Arid

DOI	10.3390/ijms21176242
	A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke
	Lucaciu, Alexandra; Kuhn, Hannah; Trautmann, Sandra; Ferreiros, Nerea; Steinmetz, Helmuth; Pfeilschifter, Josef; Brunkhorst, Robert; Pfeilschifter, Waltraud; Subburayalu, Julien; Vutukuri, Rajkumar
通讯作者	Lucaciu, A
来源期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
EISSN	1422-0067
出版年	2020
卷号	21 期号:17
英文摘要	Emerging evidence suggests a complex relationship between sphingosine 1-phosphate (S1P) signaling and stroke. Here, we show the kinetics of S1P in the acute phase of ischemic stroke and highlight accompanying changes in immune cells and S1P receptors (S1P(R)). Using a C57BL/6 mouse model of middle cerebral artery occlusion (MCAO), we assessed S1P concentrations in the brain, plasma, and spleen. We found a steep S1P gradient from the spleen towards the brain. Results obtained by qPCR suggested that cells expressing the S1P(R)type 1 (S1P(1)(+)) were the predominant population deserting the spleen. Here, we report the cerebral recruitment of T helper (T-H) and regulatory T (T-REG) cells to the ipsilateral hemisphere, which was associated with differential regulation of cerebral S1P(R)expression patterns in the brain after MCAO. This study provides insight that the S1P-S1P(R)axis facilitates splenic T cell egress and is linked to the cerebral recruitment of S1P(R)(+)T(H)and T(REG)cells. Further insights by which means the S1P-S1P(R)-axis orchestrates neuronal positioning may offer new therapeutic perspectives after ischemic stroke.
英文关键词	sphingosine 1-phosphate regulatory T helper cells stroke sphingosine kinase sphingosine 1-phosphate receptor ceramides fingolimod
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000569758200001
WOS关键词	LYMPHOCYTE EGRESS ; RECEPTOR 1 ; SPHINGOSINE-1-PHOSPHATE ; FTY720 ; EXPRESSION ; ACTIVATION ; S1P(1) ; INJURY ; BLOOD ; ACCUMULATION
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326323
作者单位	[Lucaciu, Alexandra; Kuhn, Hannah; Steinmetz, Helmuth; Brunkhorst, Robert; Pfeilschifter, Waltraud] Goethe Univ Frankfurt, Dept Neurol, D-60528 Frankfurt, Germany; [Trautmann, Sandra; Ferreiros, Nerea] Goethe Univ Frankfurt, Inst Clin Pharmacol, Pharmazentrum Frankfurt, D-60528 Frankfurt, Germany; [Pfeilschifter, Josef; Vutukuri, Rajkumar] Goethe Univ Frankfurt, Inst Gen Pharmacol & Toxicol, Pharmazentrum Frankfurt, D-60528 Frankfurt, Germany; [Brunkhorst, Robert] Rhein Westfal TH Aachen, Dept Neurol, D-52074 Aachen, Germany; [Subburayalu, Julien] Univ Cambridge, Dept Med, Cambridge CB2 0QQ, England
推荐引用方式 GB/T 7714	Lucaciu, Alexandra,Kuhn, Hannah,Trautmann, Sandra,et al. A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke[J],2020,21(17).
APA	Lucaciu, Alexandra.,Kuhn, Hannah.,Trautmann, Sandra.,Ferreiros, Nerea.,Steinmetz, Helmuth.,...&Vutukuri, Rajkumar.(2020).A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(17).
MLA	Lucaciu, Alexandra,et al."A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.17(2020).