干旱区生态环境知识资源中心(Arid): IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice

Arid

DOI	10.1016/j.taap.2020.115186
	IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice
	Berman, Reena; Kopf, Katrina W.; Min, Elysia; Huang, Jie; Downey, Gregory P.; Alam, Rafeul; Chu, Hong Wei; Day, Brian J.
通讯作者	Chu, HW
来源期刊	TOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN	0041-008X
EISSN	1096-0333
出版年	2020
卷号	404
英文摘要	Increased symptoms of asthma-like respiratory illnesses have been reported in soldiers returning from tours of duty in Afghanistan. Inhalation of desert particulate matter (PM) may contribute to this deployment-related lung disease (DRLD), but little is known about disease mechanisms. The IL-33 signaling pathway, including its receptor ST2, has been implicated in the pathogenesis of lung diseases including asthma, but its role in PM mediated airway dysfunction has not been studied. The goal of this study was to investigate whether IL-33/ST2 signaling contributes to airway dysfunction in preclinical models of lung exposure to Afghanistan PM (APM). Wild-type (WT) and ST2 knockout (KO) mice on the BALB/C background were oropharyngeally instilled with a single dose of saline or 50 mu g of APM in saline. Airway hyperresponsiveness (AHR) and inflammation were assessed after 24 h. In WT mice, a single APM exposure induced AHR and neutrophilic inflammation. Unlike the WT mice, ST2 KO mice that lack the receptor for IL-33 did not demonstrate AHR although airway neutrophilic inflammation was comparable to the WT mice. Oropharyngeal delivery of a soluble ST2 decoy receptor in APMexposed WT mice significantly blocked AHR. Additional data in mouse tracheal epithelial cell and lung macrophage cultures demonstrated a role of APM-induced IL-33/ST2 signaling in suppression of regulator of G protein signaling 2 (RGS2), a gene known to protect against bronchoconstriction. We present for the first time that APM may increase AHR, one of the features of asthma, in part through the IL-33/ST2/RGS2 pathway.
英文关键词	Particulate matter Airway hyperresponsiveness Asthma IL-33 ST2
类型	Article
语种	英语
开放获取类型	Bronze
收录类别	SCI-E
WOS记录号	WOS:000568782600005
WOS关键词	CHARACTERIZING MINERAL DUSTS ; MURINE MODEL ; CIGARETTE-SMOKE ; LUNG-FUNCTION ; INFLAMMATION ; REGULATOR ; INTERLEUKIN-33 ; RESPONSES ; MOUSE ; INVOLVEMENT
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326227
作者单位	[Berman, Reena; Chu, Hong Wei] Natl Jewish Hlth, Basic Sci Sect, Dept Med, Denver, CO 80206 USA; [Kopf, Katrina W.] Natl Jewish Hlth, Biol Resource Ctr, Denver, CO USA; [Min, Elysia; Huang, Jie; Day, Brian J.] Natl Jewish Hlth, Dept Med, Med Off Res, Denver, CO 80206 USA; [Downey, Gregory P.] Natl Jewish Hlth, Dept Med, Div Pulm Crit Care & Sleep Med, Denver, CO USA; [Alam, Rafeul] Natl Jewish Hlth, Div Allergy & Clin Immunol, Dept Med, Denver, CO USA
推荐引用方式 GB/T 7714	Berman, Reena,Kopf, Katrina W.,Min, Elysia,et al. IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice[J],2020,404.
APA	Berman, Reena.,Kopf, Katrina W..,Min, Elysia.,Huang, Jie.,Downey, Gregory P..,...&Day, Brian J..(2020).IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice.TOXICOLOGY AND APPLIED PHARMACOLOGY,404.
MLA	Berman, Reena,et al."IL-33/ST2 signaling modulates Afghanistan particulate matter induced airway hyperresponsiveness in mice".TOXICOLOGY AND APPLIED PHARMACOLOGY 404(2020).