干旱区生态环境知识资源中心(Arid): Firing up the cold tumors by targeting Vps34

Arid

DOI	10.1080/2162402X.2020.1809936
	Firing up the cold tumors by targeting Vps34
	Janji, Bassam; Hasmim, Meriem; Parpal, Santiago; Berchem, Guy; Noman, Muhammad Zaeem
通讯作者	Janji, B (corresponding author), Luxembourg Inst Hlth, Tumor Immunotherapy & Microenvironm TIME Grp, Dept Oncol, L-1526 Luxembourg, Luxembourg.
来源期刊	ONCOIMMUNOLOGY
ISSN	2162-402X
出版年	2020
卷号	9 期号:1
英文摘要	Cancer immunotherapy based on anti-PD-1/PD-L1 blockade is particularly effective in responding to patients with hot tumors. These tumors are characterized by the accumulation of proinflammatory cytokines and T cell infiltration. In our recent report published inScience Advances, we demonstrate that targeting the autophagy-related protein Vps34 switched cold immune desert tumors into hot inflamed immune-infiltrated tumors and enhanced the efficacy of anti-PD-1/PD-L1. Our study provides the preclinical rationale to set up combination immunotherapy clinical trials using selective Vps34 inhibitors and immune checkpoint blockers in melanoma and CRC.
英文关键词	Autophagy VPS34 cold hot tumors proinflammatory cytokines CCL5 CXCL10 immune landscape NK cells T CD8 lymphocytes cancer immunotherapy anti-PD-1 PD-L1 melanoma colon cancer
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000567155100001
WOS关键词	AUTOPHAGY ; GROWTH
WOS类目	Oncology ; Immunology
WOS研究方向	Oncology ; Immunology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/326129
作者单位	[Janji, Bassam; Hasmim, Meriem; Noman, Muhammad Zaeem] Luxembourg Inst Hlth LIH, Dept Oncol, Tumor Immunotherapy & Microenvironm TIME Grp, Luxembourg, Luxembourg; [Parpal, Santiago] Sprint Biosci, Stockholm, Sweden; [Parpal, Santiago] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol Pathol, Stockholm, Sweden; [Berchem, Guy] Ctr Hosp Luxembourg, Dept Hematooncol, Luxembourg, Luxembourg
推荐引用方式 GB/T 7714	Janji, Bassam,Hasmim, Meriem,Parpal, Santiago,et al. Firing up the cold tumors by targeting Vps34[J],2020,9(1).
APA	Janji, Bassam,Hasmim, Meriem,Parpal, Santiago,Berchem, Guy,&Noman, Muhammad Zaeem.(2020).Firing up the cold tumors by targeting Vps34.ONCOIMMUNOLOGY,9(1).
MLA	Janji, Bassam,et al."Firing up the cold tumors by targeting Vps34".ONCOIMMUNOLOGY 9.1(2020).