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DOI	10.1016/j.chroma.2020.461359
	Enantiomeric determination of cathinones in environmental water samples by liquid chromatography-high resolution mass spectrometry
	Fu, Yandi; Borrull, Francesc; Marce, Rosa Maria; Fontanals, Nuria
通讯作者	Marce, RM
来源期刊	JOURNAL OF CHROMATOGRAPHY A
ISSN	0021-9673
EISSN	1873-3778
出版年	2020
卷号	1626
英文摘要	The enantiomeric determination of chiral drugs in the environment is of emerging concern since their enantiomers often exhibit stereoselectivity in environmental occurrence, fate and toxicity. In this study a method based on solid-phase extraction followed by chiral liquid chromatography and high-resolution mass spectrometry has been developed for the enantiomeric determination of a group of cathinones in river water and effluent wastewater. The enantioseparation was carried out using a Chiralpak CBH column in reversed-phase mode, and optimised by evaluating the effects of flow rate, buffer concentration and organic modifier. Under optimal conditions, good enantioseparations (R-s >= 1.2) were achieved for all the analytes. Two mixed-mode cation-exchange sorbents (Oasis WCX and Oasis MCX) in solid-phase extraction were evaluated in river water. Oasis MCX sorbent showed better performance with apparent recoveries ranging from 57 to 91% and matrix effect ranging from-10 to 15%. It is worth noting that a shifting of retention times and loss of enantioresolutions in environmental water samples was observed for all the analytes when the Oasis WCX sorbent was used. The method was validated with river water and effluent wastewater samples and its overall performance was satisfactory. The method quantification limits for all the analyte enantiomers ranged from 1.0 to 2.9 ng/L in river water, and from 2.3 to 6.0 ng/L in effluent wastewater. The repeatability and reproducibility values, expressed as% relative standard deviation (n = 5) were less than 15%. The method was then applied to the analysis of river water and effluent wastewater. The racemic methylone and methedrone (EF = 0.49 and 0.46, respectively) were detected at low ng/L in some of the river water samples. (c) 2020 Elsevier B.V. All rights reserved.
英文关键词	Cathinones Enantiomeric determination Environmental waters Chiral liquid chromatography High-resolution mass spectrometry Mixed-mode ion-exchange SPE
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000564320000023
WOS关键词	SOLID-PHASE EXTRACTION ; WASTE-WATER ; SYNTHETIC CATHINONES ; PSYCHOACTIVE SUBSTANCES ; CHIRAL SEPARATION ; DESIGNER DRUGS ; ILLICIT DRUGS ; AMPHETAMINE ; SEWAGE ; EPIDEMIOLOGY
WOS类目	Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325906
作者单位	[Fu, Yandi; Borrull, Francesc; Marce, Rosa Maria; Fontanals, Nuria] Univ Rovira & Virgili, Dept Analyt Chem & Organ Chem, Sescelades Campus,Marcel Li Domingo 1, Tarragona 43007, Spain
推荐引用方式 GB/T 7714	Fu, Yandi,Borrull, Francesc,Marce, Rosa Maria,et al. Enantiomeric determination of cathinones in environmental water samples by liquid chromatography-high resolution mass spectrometry[J],2020,1626.
APA	Fu, Yandi,Borrull, Francesc,Marce, Rosa Maria,&Fontanals, Nuria.(2020).Enantiomeric determination of cathinones in environmental water samples by liquid chromatography-high resolution mass spectrometry.JOURNAL OF CHROMATOGRAPHY A,1626.
MLA	Fu, Yandi,et al."Enantiomeric determination of cathinones in environmental water samples by liquid chromatography-high resolution mass spectrometry".JOURNAL OF CHROMATOGRAPHY A 1626(2020).