干旱区生态环境知识资源中心(Arid): Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease

Arid

DOI	10.1016/j.trsl.2020.05.011
	Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease
	Dominguez-Rodriguez, Alberto; Rodriguez, Sergio; Baez-Ferrer, Nestor; Abreu-Gonzalez, Pedro; Abreu-Gonzalez, Juan; Avanzas, Pablo; Carnero, Manuel; Moris, Cesar; Lopez-Darias, Jessica; Hernandez-Vaquero, Daniel
通讯作者	Rodriguez, S
来源期刊	TRANSLATIONAL RESEARCH
ISSN	1931-5244
EISSN	1878-1810
出版年	2020
卷号	224 页码:16-25
英文摘要	Epidemiological studies found that increases in the concentrations of airborne par-ticulate matter (PM) smaller than 10 microns diameter (PM10) in the ambient air due to desert dust outbreaks contribute to global burden of diseases, primarily as a result of increased risk of cardiovascular morbidity and mortality. No studies have investi-gated the possible association between desert dust inhalation and airway inflam-mation in patients with ischemic heart disease (IHD). Induced sputum was collected in 38 patients and analyzed to determine markers of airway inflammation (Transforming Growth Factor-beta 1 [TGF-beta 1] and hydroxyproline) concentrations. For the purpose of the investigation, PM10 and reactive gases concentrations measured in the European Air Quality Network implemented in the Canary Islands were also used. We identified Saharan desert dust using meteorology and dust models. Patients affected by smoking, chronic obstructive pulmonary disease (COPD), asthma, pulmonary abnormalities, acute bronchial or pulmonary disease were excluded. The median of age of patients was 64.71 years (56.35-71.54) and 14 (38.84%) of them were women. TGF-131 and hydroxyproline in sputum were highly associated to PM10 inhalation from the Saharan desert. According to a regression model, an increase of 1mg/m(3) of PM10 concentrations due to desert dust, results in an increase of 3.84 pg/gwt of TGF-beta 1 (R-2 adjusted = 89.69%) and of 0.80 mg/gwt of hydroxyproline (R-2 adjusted = 85.28%) in the sputum of patients. The results of this study indicate that the exposure to high PM10 concentrations due to Saharan dust events are associated with intense inflammatory reaction in the airway mucosae of IHD-patients.
英文关键词	Saharan dust Particulate matter Induced sputum Airway inflammation Ischemic heart disease
类型	Article
语种	英语
开放获取类型	Green Published
收录类别	SCI-E
WOS记录号	WOS:000564312400002
WOS关键词	PARTICULATE MATTER ; DESERT DUST ; POLLUTION ; INTRUSIONS ; PARTICLES ; MORTALITY ; HEALTH
WOS类目	Medical Laboratory Technology ; Medicine, General & Internal ; Medicine, Research & Experimental
WOS研究方向	Medical Laboratory Technology ; General & Internal Medicine ; Research & Experimental Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325904
作者单位	Hosp Univ Canarias, Dept Cardiol, Tenerife, Spain; Univ Europea Canarias, Fac Ciencias Salud, Tenerife, Spain; CIBER Enfermedades CardioVasc CIBERCV, Madrid, Spain; [Rodriguez, Sergio] CSIC, EEZA, Expt Stn Arid Zones, Carretera Sacramento, Almeria 04120, Spain; CSIC, Inst Nat Prod & Agrobiol, IPNA, Tenerife, Spain; Univ La Laguna, Fac Med, Dept Physiol, Tenerife, Spain; Hosp Univ Canarias, Dept Pneumol, Tenerife, Spain; Hosp Univ Cent Asturias, Heart Area, Oviedo, Spain; Inst Invest Sanitaria Principado Asturias, Oviedo, Spain; Univ Oviedo, Dept Med, Oviedo, Spain; Hosp Clin San Carlos, Madrid, Spain; Univ La Laguna, Dept Quim, Tenerife, Spain
推荐引用方式 GB/T 7714	Dominguez-Rodriguez, Alberto,Rodriguez, Sergio,Baez-Ferrer, Nestor,et al. Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease[J],2020,224:16-25.
APA	Dominguez-Rodriguez, Alberto.,Rodriguez, Sergio.,Baez-Ferrer, Nestor.,Abreu-Gonzalez, Pedro.,Abreu-Gonzalez, Juan.,...&Hernandez-Vaquero, Daniel.(2020).Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease.TRANSLATIONAL RESEARCH,224,16-25.
MLA	Dominguez-Rodriguez, Alberto,et al."Impact of Saharan dust exposure on airway inflammation in patients with ischemic heart disease".TRANSLATIONAL RESEARCH 224(2020):16-25.