干旱区生态环境知识资源中心(Arid): Coccidioides (spherulin) skin testing in patients with pulmonary coccidioidomycosis in an endemic region

Arid

DOI	10.1093/mmy/myz099
	Coccidioides (spherulin) skin testing in patients with pulmonary coccidioidomycosis in an endemic region
	Mafi, Neema; Murphy, C. Brian; Girardo, Marlene E.; Blair, Janis E.
通讯作者	Blair, JE
来源期刊	MEDICAL MYCOLOGY
ISSN	1369-3786
EISSN	1460-2709
出版年	2020
卷号	58 期号:5 页码:626-631
英文摘要	Coccidioidomycosis is an endemic fungal infection of the desert southwestern United States. Intact cellular immunity is critical to the control of this infection. A recently released reformulated spherulin antigen (Spherusol; Nielsen BioSciences, Inc.) was approved to detect delayed-type hypersensitivity, which implies the presence of cellular immunity, to Coccidioides species. We aimed to summarize our experience with this test in patients with primary pulmonary coccidioidomycosis. We retrospectively reviewed clinical data for all patients with primary pulmonary coccidioidomycosis who had a Coccidioides (spherulin) skin test (CST) placed at our institution between January 1, 2015, and August 31, 2017. During the study period, 172 patients had a CST placed, and 122 met our inclusion criteria for proven or probable pulmonary coccidioidomycosis. Of these 122, 88 (72.1%) had a positive CST result and 34 (27.9%) had a negative result. In the positive CST group, 74 of the 79 treated patients (93.7%) had antifungal treatment stopped, 1 of whom (1.4%) had relapsed infection. In contrast, 27 of the 33 treated patients in the negative CST group (81.8%) had their antifungal treatment stopped, and none had a relapse. Seven patients overall (5.7%), all of whom had a positive CST, experienced mild local adverse reactions to the CST. Although previous controlled studies of CST showed sensitivity and specificity greater than 98%, our real-world experience with the CST showed lower rates of positivity. Negative CST results did not predict relapse with antifungal agent withdrawal.
英文关键词	Coccidioides coccidioidomycosis fungal infection pneumonia skin testing
类型	Article
语种	英语
收录类别	SSCI
WOS记录号	WOS:000562474500007
WOS关键词	DELAYED-TYPE HYPERSENSITIVITY ; REACTIVITY ; IMMUNITY ; DISEASE
WOS类目	Infectious Diseases ; Mycology ; Veterinary Sciences
WOS研究方向	Infectious Diseases ; Mycology ; Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325811
作者单位	[Mafi, Neema; Blair, Janis E.] Mayo Clin Hosp, Div Infect Dis, 5777 E Mayo Blvd, Phoenix, AZ 85054 USA; [Murphy, C. Brian] Mayo Clin, Dept Internal Med, Scottsdale, AZ USA; [Girardo, Marlene E.] Mayo Clin, Biostat, Scottsdale, AZ USA
推荐引用方式 GB/T 7714	Mafi, Neema,Murphy, C. Brian,Girardo, Marlene E.,et al. Coccidioides (spherulin) skin testing in patients with pulmonary coccidioidomycosis in an endemic region[J],2020,58(5):626-631.
APA	Mafi, Neema,Murphy, C. Brian,Girardo, Marlene E.,&Blair, Janis E..(2020).Coccidioides (spherulin) skin testing in patients with pulmonary coccidioidomycosis in an endemic region.MEDICAL MYCOLOGY,58(5),626-631.
MLA	Mafi, Neema,et al."Coccidioides (spherulin) skin testing in patients with pulmonary coccidioidomycosis in an endemic region".MEDICAL MYCOLOGY 58.5(2020):626-631.