干旱区生态环境知识资源中心(Arid): OASIS-a randomised, placebo-controlled trial of oral glucocorticoids for leg pain in patients with acute sciatica: trial protocol

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DOI	10.1136/bmjopen-2020-040559
	OASIS-a randomised, placebo-controlled trial of oral glucocorticoids for leg pain in patients with acute sciatica: trial protocol
	Liu, Chang; Shaheed, Christina Abdel; McLachlan, Andrew J.; Latimer, Jane; Li, Qiang; Buchbinder, Rachelle; Day, Richard O.; Maher, Christopher G.; Richards, Bethan; Oliveira, Juliana S.; Lin, Chung-Wei Christine
通讯作者	Liu, C
来源期刊	BMJ OPEN
ISSN	2044-6055
出版年	2020
卷号	10 期号:6
英文摘要	Introduction Sciatica is a lower spine condition characterised by radiating leg pain below the knee. It may be accompanied by motor and sensory loss in the distribution of a spinal nerve. There are few effective treatments for sciatica. Orally administered glucocorticoids have shown some promise, however, any beneficial effects need to be confirmed and weighed against drug safety and cost-effectiveness, in a high-quality, definitive trial. Methods and analysis The Oral Steroids In Sciatica (OASIS) trial is a randomised, placebo-controlled, double-blind trial that will evaluate a tapering regimen of oral prednisolone in 200 participants with acute sciatica. Participants will be recruited on presentation to general practice, specialist outpatient clinics or hospital emergency departments and randomised to receive orally administered prednisolone 50mg per day, up to 3 days then tapering to cessation over 10 days, or placebo, for a maximum of 13 days, in addition to guideline advice. Participants will be followed for 1year. The primary endpoint will be leg pain intensity at 2 weeks. Secondary outcomes will include back pain intensity, disability, time to recovery, quality of life and treatment success rate. Adverse events will be assessed and a cost-effectiveness analysis will be conducted. Ethics and dissemination Ethical approval has been granted from the Human Research Ethics Committee, The University of Sydney. Trial results will be disseminated by publications and conference presentations and via the media. Trial registration number ACTRN12619001716156.
英文关键词	musculoskeletal disorders pain management spine clinical trials
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000561434500066
WOS关键词	LOW-BACK-PAIN ; EPIDURAL CORTICOSTEROID INJECTIONS ; CLINICAL-TRIALS ; LUMBAR-DISK ; HEALTH ; RADICULOPATHY ; OUTCOMES ; PREVALENCE
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325745
作者单位	[Liu, Chang; Shaheed, Christina Abdel; Latimer, Jane; Maher, Christopher G.; Richards, Bethan; Oliveira, Juliana S.; Lin, Chung-Wei Christine] Univ Sydney, Inst Musculoskeletal Hlth, Sydney, NSW, Australia; [Liu, Chang; Shaheed, Christina Abdel; Latimer, Jane; Maher, Christopher G.; Richards, Bethan; Oliveira, Juliana S.; Lin, Chung-Wei Christine] Sydney Local Hlth Dist, Sydney, NSW, Australia; [Liu, Chang; Shaheed, Christina Abdel; Latimer, Jane; Maher, Christopher G.; Richards, Bethan; Oliveira, Juliana S.; Lin, Chung-Wei Christine] Univ Sydney, Fac Med & Hlth, Sch Publ Hlth, Sydney, NSW, Australia; [McLachlan, Andrew J.] Univ Sydney, Sydney Pharm Sch, Sydney, NSW, Australia; [Li, Qiang] Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia; [Buchbinder, Rachelle] Monash Univ, Sch Publ Hlth & Prevent Med, Dept Epidemiol & Prevent Med, Victoria, Australia; [Buchbinder, Rachelle] Cabrini Inst, Monash Dept Clin Epidemiol, Melbourne, Vic, Australia; [Day, Richard O.] St Vincent Hosp, Dept Cl...
推荐引用方式 GB/T 7714	Liu, Chang,Shaheed, Christina Abdel,McLachlan, Andrew J.,et al. OASIS-a randomised, placebo-controlled trial of oral glucocorticoids for leg pain in patients with acute sciatica: trial protocol[J],2020,10(6).
APA	Liu, Chang.,Shaheed, Christina Abdel.,McLachlan, Andrew J..,Latimer, Jane.,Li, Qiang.,...&Lin, Chung-Wei Christine.(2020).OASIS-a randomised, placebo-controlled trial of oral glucocorticoids for leg pain in patients with acute sciatica: trial protocol.BMJ OPEN,10(6).
MLA	Liu, Chang,et al."OASIS-a randomised, placebo-controlled trial of oral glucocorticoids for leg pain in patients with acute sciatica: trial protocol".BMJ OPEN 10.6(2020).