干旱区生态环境知识资源中心(Arid): What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?

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DOI	10.1177/1073274820941968
	What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?
	Miller, Anna K.; Brown, Joel S.; Basanta, David; Huntly, Nancy
通讯作者	Miller, AK
来源期刊	CANCER CONTROL
ISSN	1073-2748
出版年	2020
卷号	27 期号:3
英文摘要	Intratumor heterogeneity is a feature of cancer that is associated with progression, treatment resistance, and recurrence. However, the mechanisms that allow diverse cancer cell lineages to coexist remain poorly understood. The storage effect is a coexistence mechanism that has been proposed to explain the diversity of a variety of ecological communities, including coral reef fish, plankton, and desert annual plants. Three ingredients are required for there to be a storage effect: (1) temporal variability in the environment, (2) buffered population growth, and (3) species-specific environmental responses. In this article, we argue that these conditions are observed in cancers and that it is likely that the storage effect contributes to intratumor diversity. Data that show the temporal variation within the tumor microenvironment are needed to quantify how cancer cells respond to fluctuations in the tumor microenvironment and what impact this has on interactions among cancer cell types. The presence of a storage effect within a patient's tumors could have a substantial impact on how we understand and treat cancer.
英文关键词	storage effect cancer heterogeneity coexistence dormancy quiescence fluctuating environments
类型	Editorial Material
语种	英语
开放获取类型	DOAJ Gold, Green Published
收录类别	SCI-E
WOS记录号	WOS:000561416300001
WOS关键词	DRUG-RESISTANCE ; CELL DORMANCY ; HETEROGENEITY ; COEXISTENCE ; MODELS ; EVOLUTION ; DYNAMICS ; INVASION ; MECHANISMS ; PROMOTES
WOS类目	Oncology
WOS研究方向	Oncology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325744
作者单位	[Miller, Anna K.; Brown, Joel S.; Basanta, David] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, USF Magnolia Dr, Tampa, FL 33612 USA; [Huntly, Nancy] Utah State Univ, Ctr Ecol, Logan, UT 84322 USA; [Huntly, Nancy] Utah State Univ, Dept Biol, Logan, UT 84322 USA
推荐引用方式 GB/T 7714	Miller, Anna K.,Brown, Joel S.,Basanta, David,et al. What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?[J],2020,27(3).
APA	Miller, Anna K.,Brown, Joel S.,Basanta, David,&Huntly, Nancy.(2020).What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?.CANCER CONTROL,27(3).
MLA	Miller, Anna K.,et al."What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?".CANCER CONTROL 27.3(2020).