干旱区生态环境知识资源中心(Arid): Genome Diversity and the Origin of the Arabian Horse

Arid

DOI	10.1038/s41598-020-66232-1
	Genome Diversity and the Origin of the Arabian Horse
	Cosgrove, Elissa J.; Sadeghi, Raheleh; Schlamp, Florencia; Holl, Heather M.; Moradi-Shahrbabak, Mohammad; Miraei-Ashtiani, Seyed Reza; Abdalla, Salma; Shykind, Ben; Troedsson, Mats; Stefaniuk-Szmukier, Monika; Prabhu, Anil; Bucca, Stefania; Bugno-Poniewierska, Monika; Wallner, Barbara; Malek, Joel; Miller, Donald C.; Clark, Andrew G.; Antczak, Douglas F.; Brooks, Samantha A.
通讯作者	Brooks, SA
来源期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
出版年	2020
卷号	10 期号:1
英文摘要	The Arabian horse, one of the world's oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabian horses from 12 countries using equine single nucleotide polymorphism (SNP) arrays and whole-genome re-sequencing to examine hypotheses about genomic diversity, population structure, and the relationship of the Arabian to other horse breeds. We identified a high degree of genetic variation and complex ancestry in Arabian horses from the Middle East region. Also, contrary to popular belief, we could detect no significant genomic contribution of the Arabian breed to the Thoroughbred racehorse, including Y chromosome ancestry. However, we found strong evidence for recent interbreeding of Thoroughbreds with Arabians used for flat-racing competitions. Genetic signatures suggestive of selective sweeps across the Arabian breed contain candidate genes for combating oxidative damage during exercise, and within the Straight Egyptian subgroup, for facial morphology. Overall, our data support an origin of the Arabian horse in the Middle East, no evidence for reduced global genetic diversity across the breed, and unique genetic adaptations for both physiology and conformation.
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000560497400014
WOS关键词	POPULATION-STRUCTURE ; GENETIC DIVERSITY ; DNA ; EXERCISE ; MUTATION ; SELENIUM ; DISEASE ; TOOL
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325680
作者单位	[Cosgrove, Elissa J.; Schlamp, Florencia; Clark, Andrew G.] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA; [Sadeghi, Raheleh; Miller, Donald C.; Antczak, Douglas F.] Cornell Univ, Coll Vet Med, Baker Inst Anim Hlth, Ithaca, NY 14853 USA; [Holl, Heather M.; Brooks, Samantha A.] Univ Florida, UF Genet Inst, Dept Anim Sci, Gainesville, FL 32610 USA; [Sadeghi, Raheleh; Moradi-Shahrbabak, Mohammad; Miraei-Ashtiani, Seyed Reza] Univ Tehran, Coll Agr & Nat Resources, Dept Anim Sci, Karaj, Iran; [Abdalla, Salma; Shykind, Ben] Weill Cornell Med Coll Qatar, Dept Cell & Dev Biol & Biochem, Doha, Qatar; [Shykind, Ben] Prevail Therapeut, New York, NY 10016 USA; [Troedsson, Mats] Univ Kentucky, Maxwell H Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA; [Stefaniuk-Szmukier, Monika; Bugno-Poniewierska, Monika] Agr Univ Krakow, Dept Anim Reprod Anat & Genom, Krakow, Poland; [Prabhu, Anil] Hong Kong JockeyClub, Equine Hosp Sha Tin Racecourse, Hong Kong, Peoples R China; [Troedsson, Mats; Bucca, Stef...
推荐引用方式 GB/T 7714	Cosgrove, Elissa J.,Sadeghi, Raheleh,Schlamp, Florencia,et al. Genome Diversity and the Origin of the Arabian Horse[J],2020,10(1).
APA	Cosgrove, Elissa J..,Sadeghi, Raheleh.,Schlamp, Florencia.,Holl, Heather M..,Moradi-Shahrbabak, Mohammad.,...&Brooks, Samantha A..(2020).Genome Diversity and the Origin of the Arabian Horse.SCIENTIFIC REPORTS,10(1).
MLA	Cosgrove, Elissa J.,et al."Genome Diversity and the Origin of the Arabian Horse".SCIENTIFIC REPORTS 10.1(2020).