干旱区生态环境知识资源中心(Arid): Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity

Arid

DOI	10.1016/j.arabjc.2020.06.022
	Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity - Part A
	Makeen, Hafiz A.; Menachery, Santhosh Joseph; Moni, Sivakumar Sivagurunathan; Alqahtani, Saad Saeed; Rehman, Zia ur; Alam, Md Shamsher; Mohan, Syam; Albratty, Mohammed
通讯作者	Moni, SS
来源期刊	ARABIAN JOURNAL OF CHEMISTRY
ISSN	1878-5352
EISSN	1878-5379
出版年	2020
卷号	13 期号:8 页码:6672-6681
英文摘要	Caralluma retrospiciens (Ehrenb) is a desert plant widely distributed in the hilly semidesert regions of southern part of Saudi Arabia. The exudate gel (EG) from the stem of plant is occasionally used for wound healing by the people of the southern part of Saudi Arabia. This study investigated the phytochemical composition, FT-IR, GC-MS spectral analysis and in vitro antibacterial activity of the EG from the stem of C. retrospiciens (Ehrenb). The plant C. retrospiciens (Ehrenb.) was collected from the hills of Rijal Almaa, a heritage village of Saudi Arabia. The EG was isolated from the stem of C. retrospiciens (Ehrenb.). Physical parameters such as viscosity and zeta potential (ZP) were determined. Phytochemical analysis, FT-IR and GC-MS spectroscopy analysis were performed to determine the bio active constituents. The antibacterial activity of the isolated gel was performed by in vitro agar well diffusion technique. The study demonstrated that the viscosity and ZP of EG influenced the efficacy of antibacterial spectral properties. The FT-IR spectroscopy of the EG showed various functional groups at 3278.29, 2951.16, 2840.44, 2527.55, 2161.67, 1647.40, 1450.06, 1406.7, 1286, 1108.34, 5536.63 cm(-1). Various pharmaceutically important chemical compounds were identified using GC-MS analysis. The bioactive compounds are "Sorbic Acid", "Rhodopsin", "1-Heptatriacotanol", "Oxiraneundecanoic acid, 3-pentyl-, methyl ester, trans", "Cholestan-3-ol, 2-methylene-, (3a,5a)", "Benzoic acid", "3-pentyl-, methyl ester trans", "Hexanoic acid, 2-ethyl-, oxybis (2,1-ethanediyloxy-2,1-ethanediyl) ester", etc. The antibacterial effect of the EG showed a wide spectrum of activity against the screened human pathogenic bacteria. The results demonstrate the bioactive principles of EG from C. retrospiciens (Ehrenb.) exerts the antibacterial properties in vitro. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
英文关键词	Desert plant Caralluma retrospiciens (Ehrenb.) Phytochemicals Antibacterial effect Gram-positive and Gramnegative bacteria
类型	Article
语种	英语
开放获取类型	DOAJ Gold
收录类别	SCI-E
WOS记录号	WOS:000554775400024
WOS类目	Chemistry, Multidisciplinary
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325347
作者单位	[Makeen, Hafiz A.; Menachery, Santhosh Joseph; Alqahtani, Saad Saeed] Jazan Univ, Clin Pharm Dept, Fac Pharm, Pharm Practice Res Unit, Jazan, Saudi Arabia; [Makeen, Hafiz A.; Mohan, Syam; Albratty, Mohammed] Jazan Univ, Ethnopharmacol Res Unit, Jazan, Saudi Arabia; [Moni, Sivakumar Sivagurunathan] Jazan Univ, Dept Pharmaceut, Fac Pharm, POB 114, Jazan 45142, Saudi Arabia; [Rehman, Zia ur; Alam, Md Shamsher; Albratty, Mohammed] Jazan Univ, Dept Pharmaceut Chem, Jazan, Saudi Arabia; [Mohan, Syam] Jazan Univ, Subst Abuse & Toxicol Res Ctr, Jazan, Saudi Arabia
推荐引用方式 GB/T 7714	Makeen, Hafiz A.,Menachery, Santhosh Joseph,Moni, Sivakumar Sivagurunathan,et al. Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity - Part A[J],2020,13(8):6672-6681.
APA	Makeen, Hafiz A..,Menachery, Santhosh Joseph.,Moni, Sivakumar Sivagurunathan.,Alqahtani, Saad Saeed.,Rehman, Zia ur.,...&Albratty, Mohammed.(2020).Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity - Part A.ARABIAN JOURNAL OF CHEMISTRY,13(8),6672-6681.
MLA	Makeen, Hafiz A.,et al."Documentation of bioactive principles of the exudate gel (EG) from the stem of Caralluma retrospiciens (Ehrenb) and in vitro antibacterial activity - Part A".ARABIAN JOURNAL OF CHEMISTRY 13.8(2020):6672-6681.