干旱区生态环境知识资源中心(Arid): alpha-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects ofEuphorbia nivulia-Ham. in STZ-Induced Diabetic Rats

Arid

DOI	10.1177/1559325820939429
	alpha-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects ofEuphorbia nivulia-Ham. in STZ-Induced Diabetic Rats
	Younus, Muhammad; ul Hasan, Muhammad Mohtasheem; Ahmad, Khalil; Sharif, Ali; Asif, Hafiz Muhammad; Aslam, Muhammad Rahil; ul Haq, Ihsan; Ahmad, Zulfiqar
通讯作者	Younus, M
来源期刊	DOSE-RESPONSE
ISSN	1559-3258
出版年	2020
卷号	18 期号:3
英文摘要	In this study, we aimed to investigate the antidiabetic effects ofEuphorbia nivulia (En), native to Cholistan Desert area of Bahawalpur, Pakistan. First, we performed high-performance liquid chromatography analysis and found that this plant contains ferulic acid, gallic acid, quercetin, benzoic acid, polyphenols, and flavonoids. Then, we performed in vitro and in vivo studies to assess its effects on diabetic Wistar rat model. The experiments were performed and compared with control drug glibenclamide. The 70% hydroalcoholic extract ofEnexhibited 97.8% in vitro alpha-glucosidase inhibitory effect at a dose of 1.0 mg/mL. We orally administered the extract ofEnand control drug to the streptozotocin (STZ)-induced diabetic rats and analyzed its antidiabetic effects. We found that the extract ofEnwith a dose of 500 mg/kg/body weight exhibited significant effect to reduce blood glucose in STZ-induced rats as compared with the control group (P< .001). Our histological data also showed that the extract significantly improved the histopathology of pancreas. Collectively, both in vitro and in vivo studies revealed thatEnpossesses alpha-glucosidase inhibitory, antioxidant, and anti-hyperglycemic effect in STZ-induced diabetic rats.
英文关键词	Euphorbia nivulia antioxidants flavonoids medicinal plants antidiabetic
类型	Article
语种	英语
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000549163200001
WOS关键词	ANTIDIABETIC ACTIVITY ; HERBAL FORMULATION ; CLINICAL-EFFICACY ; MEDICINAL-PLANTS ; EXTRACT ; DERIVATIVES ; MANAGEMENT ; ACTIVATOR ; DISEASE ; FLOWERS
WOS类目	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Radiology, Nuclear Medicine & Medical Imaging ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325064
作者单位	[Younus, Muhammad; ul Hasan, Muhammad Mohtasheem] Univ Karachi, Fac Pharm & Pharmaceut Sci, Dept Pharmacognosy, Karachi, Pakistan; [Younus, Muhammad] Islamia Univ Bahawalpur, Fac Pharm & Alternat Med, Dept Pharm, Bahawalpur, Pakistan; [Ahmad, Khalil; Asif, Hafiz Muhammad; Aslam, Muhammad Rahil] Islamia Univ Bahawalpur, Univ Coll Convent Med, Fac Pharm & Alternat Med, Bahawalpur, Pakistan; [Sharif, Ali] Lahore Coll Women Univ, Fac Pharmaceut & Allied Hlth Sci, Inst Pharm, Dept Pharmacol, Lahore, Pakistan; [ul Haq, Ihsan] Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad, Pakistan; [Ahmad, Zulfiqar] Islamia Univ Bahawalpur, Univ Coll Agr & Environm Sci, Dept Food Sci & Technol, Bahawalpur, Pakistan
推荐引用方式 GB/T 7714	Younus, Muhammad,ul Hasan, Muhammad Mohtasheem,Ahmad, Khalil,et al. alpha-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects ofEuphorbia nivulia-Ham. in STZ-Induced Diabetic Rats[J],2020,18(3).
APA	Younus, Muhammad.,ul Hasan, Muhammad Mohtasheem.,Ahmad, Khalil.,Sharif, Ali.,Asif, Hafiz Muhammad.,...&Ahmad, Zulfiqar.(2020).alpha-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects ofEuphorbia nivulia-Ham. in STZ-Induced Diabetic Rats.DOSE-RESPONSE,18(3).
MLA	Younus, Muhammad,et al."alpha-Glucosidase Inhibitory, Anti-Oxidant, and Anti-Hyperglycemic Effects ofEuphorbia nivulia-Ham. in STZ-Induced Diabetic Rats".DOSE-RESPONSE 18.3(2020).