干旱区生态环境知识资源中心(Arid): Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS)

Arid

DOI	10.1080/15287394.2020.1780658
	Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS)
	Silva, Jurandy do Nascimento; Nery Moncao, Nayana Bruna; Soares de Farias, Ruth Raquel; das Gracas Lopes Cito, Antonia Maria; Chaves, Mariana Helena; Silva de Araujo, Monica Regina; Barbosa Lima, Daisy Jereissati; Pessoa, Claudia; de Lima, Alessandro; da Cruz Araujo, Edigenia Cavalcante; Gadelha Militao, Gardenia Carmen; da Costa, Marcilia Pinheiro; Capasso, Raffaele; Pinheiro Ferreira, Paulo Michel
通讯作者	Ferreira, PMP
来源期刊	JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
ISSN	1528-7394
EISSN	1087-2620
出版年	2020
卷号	83 期号:13-14 页码:525-545
英文摘要	Caatinga flora which are found in a poor Brazilian region contain a substantial number of endemic taxa with biomedical and social importance for regional communities. This study examined the antioxidant and cytotoxic potential of 35 samples (extracts/fractions) from 12 Caatinga species and determined the antiproliferative and genotoxic action of dichloromethane fraction fromMimosa caesalpiniifoliastem bark (DC-Mca) on human and vegetal cells. Samples were assessed for chemopreventive ability, toxic effects onArtemia salinashrimp as well as cytotoxicity on tumor cell lines and erythrocytes. DC-Mca was also tested with respect to antiproliferative and genotoxic effects upon normal leukocytes and meristematic cells fromA. ceparoots. Some extracts reduced free radical levels >95% and 7 samples exhibited a lethal concentration (LC)(50) Artemia salinalarvae. Eight samples displayedin vitroantitumor effects and three produced hemolysis. Data also demonstrated the pharmacological significance of bioactive extracts from Brazilian semi-arid region. There was no significant relationship between antioxidant, toxic, and antiproliferative activities, and that these properties were dependent upon the extractant. DC-Mca contained betulinic acid as main compound (approximately 70%), which showed higher (1) cytotoxic activity on cancer cell lines and dividing leukocytes, (2) reduced mitotic index ofAllium ceparoots, and (3) induced cell cycle arrest and chromosomal bridges, thereby providing native promising sources for phytotherapy development.
英文关键词	Oxidative stress antitumoral action genotoxicity cell cycle arrest environmental toxicology
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000547662400004
WOS关键词	MIMOSA-CAESALPINIIFOLIA BENTH. ; CAATINGA SEMIARID VEGETATION ; ACID-INDUCED APOPTOSIS ; BETULINIC ACID ; MEDICINAL-PLANTS ; ANTIOXIDANT CAPACITY ; IN-VIVO ; CHEMICAL-CONSTITUENTS ; ETHANOLIC EXTRACT ; LEAVES
WOS类目	Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/325010
作者单位	[Silva, Jurandy do Nascimento; Pinheiro Ferreira, Paulo Michel] Univ Fed Piaui, Dept Physiol & Biophys, Lab Expt Cancerol, Teresina, Brazil; [Nery Moncao, Nayana Bruna; Soares de Farias, Ruth Raquel; das Gracas Lopes Cito, Antonia Maria; Chaves, Mariana Helena] Univ Fed Piaui, Dept Chem, Teresina, Brazil; [Silva de Araujo, Monica Regina] Univ Int Integrat Afro Brazilian Lusophony, Dept Exact & Nat Sci, Redencao, Brazil; [Barbosa Lima, Daisy Jereissati; Pessoa, Claudia] Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil; [de Lima, Alessandro] Fed Inst Educ Sci & Technol Piaui, Teresina, Brazil; [da Cruz Araujo, Edigenia Cavalcante] Fed Univ Vale do Sao Francisco, Dept Pharmaceut Sci, Petrolina, Brazil; [Gadelha Militao, Gardenia Carmen] Univ Fed Pernambuco, Dept Physiol & Pharmacol, Recife, PE, Brazil; [Capasso, Raffaele] Univ Fed Piaui, Dept Pharm, Teresina, Brazil; [Capasso, Raffaele] Univ Naples Federico II, Dept Agr Sci, Naples, Italy
推荐引用方式 GB/T 7714	Silva, Jurandy do Nascimento,Nery Moncao, Nayana Bruna,Soares de Farias, Ruth Raquel,et al. Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS)[J],2020,83(13-14):525-545.
APA	Silva, Jurandy do Nascimento.,Nery Moncao, Nayana Bruna.,Soares de Farias, Ruth Raquel.,das Gracas Lopes Cito, Antonia Maria.,Chaves, Mariana Helena.,...&Pinheiro Ferreira, Paulo Michel.(2020).Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS).JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES,83(13-14),525-545.
MLA	Silva, Jurandy do Nascimento,et al."Toxicological, chemopreventive, and cytotoxic potentialities of rare vegetal species and supporting findings for the Brazilian Unified Health System (SUS)".JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES 83.13-14(2020):525-545.