干旱区生态环境知识资源中心(Arid): Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys

Arid

DOI	10.1016/j.theriogenology.2020.04.041
	Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys
	French, Hilari; Peterson, Erik; Schulman, Martin; Roth, Robyn; Crampton, Michael; Conan, Anne; Marchi, Silvia; Knobel, Darryn; Bertschinger, Henk
通讯作者	Bertschinger, H
来源期刊	THERIOGENOLOGY
ISSN	0093-691X
EISSN	1879-3231
出版年	2020
卷号	153 页码:27-33
英文摘要	Feral and semi-feral donkeys are recognised as a problem in some world regions. The main problem associated with uncontrolled donkey populations is habitat degradation and competition for feed resources, especially in arid climes. Controlling population numbers would reduce the impact of donkeys and other species. While removal by various means is effective, it has been shown to stimulate reproductive rate. Probably the most effective and humane solution is reducing reproduction using minimally invasive methods including immunocontraception. This study tested the immunocontraceptive efficacy and safety of zona pellucida (ZP) vaccines, both recombinant (reZP; three treatments) and native porcine (pZP; two treatments) vaccines formulated with Freund's modified complete (primary) and Freund's incomplete (boosters) adjuvants in donkey jennies. Control jennies received adjuvants only (two treatments). Twenty-five non-pregnant jennies were randomly assigned to reZP (n = 9), pZP (n = 8) or control (n = 8) groups. Weekly monitoring of the reproductive tract and ovaries via transrectal palpation and ultrasound and inspection of injection sites was conducted and anti-pZP antibody titers were measured. Five weeks after last treatment, one donkey jack was introduced to each group and rotated every 21 days. By 232 days after last treatment the number pregnant and median days to pregnancy was 2/9 and 214 (reZP group), 1/8 and 196 (pZP group) and 8/8 and 77 (control group). Median time to ovarian shut-down was 77 (9/9) and 56 (7/8) days for reZP and pZP groups, respectively. This was observed in association with a distinct reduction in mean uterine diameter. The antibody response was equally good for both ZP-treated groups. Incorporation of Freund's adjuvants initially produced a high incidence of side effects from local swelling and intermittent lameness followed weeks later by sterile abscesses (reZP, 9/9; pZP, 7/8; control, 3/8). Both ZP vaccines effectively controlled reproduction in jennies, albeit with a high incidence of adjuvant-associated side effects. 0 2020 Elsevier Inc. All rights reserved. (C) 2020 Elsevier Inc. All rights reserved.
英文关键词	Recombinant and native zona pellucida vaccines Immunocontraception Donkeys Fertility Ovarian suppression anti-pZP antibody titers
类型	Article
语种	英语
收录类别	SCI-E
WOS记录号	WOS:000540764600004
WOS关键词	REMOTELY-DELIVERED IMMUNOCONTRACEPTION ; OVARIAN-FUNCTION ; PORCINE ; BURROS ; HORSES
WOS类目	Reproductive Biology ; Veterinary Sciences
WOS研究方向	Reproductive Biology ; Veterinary Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/324775
作者单位	[French, Hilari; Peterson, Erik; Conan, Anne; Marchi, Silvia; Knobel, Darryn] Ross Univ, Sch Vet Med, POB 334, Basseterre, St Kitts & Nevi; [Schulman, Martin; Bertschinger, Henk] Univ Pretoria, Fac Vet Sci, Dept Prod Anim Studies, Vet Populat Management Lab,Sect Reprod, Pretoria, South Africa; [Roth, Robyn; Crampton, Michael] CSIR, Pretoria, South Africa; [Knobel, Darryn] Univ Pretoria, Dept Vet Trop Dis, Pretoria, South Africa
推荐引用方式 GB/T 7714	French, Hilari,Peterson, Erik,Schulman, Martin,et al. Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys[J],2020,153:27-33.
APA	French, Hilari.,Peterson, Erik.,Schulman, Martin.,Roth, Robyn.,Crampton, Michael.,...&Bertschinger, Henk.(2020).Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys.THERIOGENOLOGY,153,27-33.
MLA	French, Hilari,et al."Efficacy and safety of native and recombinant zona pellucida immunocontraceptive vaccines in donkeys".THERIOGENOLOGY 153(2020):27-33.