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| DOI | 10.3233/JAD-200102 |
| Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements | |
| Lu, Hanna1,2,3 | |
| 通讯作者 | Lu, Hanna |
| 来源期刊 | JOURNAL OF ALZHEIMERS DISEASE
 |
| ISSN | 1387-2877 |
| EISSN | 1875-8908 |
| 出版年 | 2020 |
| 卷号 | 76期号:2页码:505-516 |
| 英文摘要 | Background: Cortical complexity plays a central role in the diagnosis and prognosis of age-related diseases. However, little is known about the regional cortical complexity in the context of brain atrophy. Objective: We aimed to systematically examine the age-related changes of the cortical complexity of left dorsolateral prefrontal cortex (DLPFC) and its subregions. Methods: Two hundred and fourteen cognitively normal adults drawn from the Open Access Series of Imaging Studies (OASIS) were divided into four age groups: young, middle-aged, young-old, and old-old. Based on structural magnetic resonance imaging (sMRI) scans, the multiscale measures of cortical complexity included cortical thickness (mm), surface area (mm(2)), grey matter volume (mm(3)), density, gyrification index (GI), and fractal dimension (FD). Results: Advancing age was associated with reduced grey matter volume, pial surface area, density, and FD of left DLPFC, but correlated with increased cortical thickness and GI. Volumetric measures, cerebrospinal fluid volume in particular, showed better performance to discriminate young-old adults from old-old adults, while FD was more sensitive than the volumetric measures to discriminate young adults and middle-aged adults. Conclusion: This is the first demonstration that chronological age has a pronounced and differential effect on the cortical complexity of left DLPFC. Our findings suggest that surface-based measures of cortical region, thickness, and gyrification in particular, could be considered as valuable imaging markers for the studies of aging brain and neurodegenerative diseases. |
| 英文关键词 | Cortical complexity cortical thickness dorsolateral prefrontal cortex folding fractal dimension grey matter gyrification |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Peoples R China |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000551104100009 |
| WOS关键词 | PARKINSONS-DISEASE ; FRACTAL DIMENSION ; SURFACE ; BRAIN ; DEPRESSION ; IDENTIFICATION ; THICKNESS ; PATTERNS ; GRAY |
| WOS类目 | Neurosciences |
| WOS研究方向 | Neurosciences & Neurology |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/319625 |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China; 2.Guangdong Engn Technol Res Ctr Translat Med Menta, Guangzhou, Peoples R China; 3.Guangzhou Med Univ, Affiliated Brain Hosp, Guangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Hanna. Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements[J],2020,76(2):505-516. |
| APA | Lu, Hanna.(2020).Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements.JOURNAL OF ALZHEIMERS DISEASE,76(2),505-516. |
| MLA | Lu, Hanna."Quantifying Age-Associated Cortical Complexity of Left Dorsolateral Prefrontal Cortex with Multiscale Measurements".JOURNAL OF ALZHEIMERS DISEASE 76.2(2020):505-516. |
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