Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3390/ijerph17114067 |
| Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province | |
| Vumazonke, Sesethu1; Khamanga, Sandile Maswazi2; Ngqwala, Nosiphiwe Patience1 | |
| 通讯作者 | Ngqwala, Nosiphiwe Patience |
| 来源期刊 | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
 |
| EISSN | 1660-4601 |
| 出版年 | 2020 |
| 卷号 | 17期号:11 |
| 英文摘要 | Pharmaceuticals are emerging contaminants in the aquatic environments. Their presence poses toxicological effects in humans and animals even at trace concentrations. This study investigated the presence of antibiotics, anti-epilepsy and anti-inflammatory drugs in river water of selected rivers in the Eastern Cape Province in South Africa. Enzyme-linked immunosorbent assay was used for screening of sulfamethoxazole and fluoroquinolones antibiotics. The samples were collected in upper-stream, middle-stream and lower-stream regions of the rivers and effluent of selected wastewater treatment plants. Pre-concentration of the samples was conducted using lyophilisation and extraction was conducted using solid phase extraction (SPE) on Waters Oasis hydrophilic-lipophilic-balanced cartridge. The percentage recovery after sample clean-up on SPE was 103% +/- 6.9%. This was followed by ultra-performance liquid chromatography electrospray ionization tandem mass spectrometry. The detected analytes were sulfamethoxazole, erythromycin, clarithromycin and carbamazepine. Carbamazepine and erythromycin were detected in high concentrations ranging from 81.8 to 36,576.2 ng/L and 11.2 to 11,800 ng/L respectively, while clarithromycin and sulfamethoxazole were detected at moderate concentrations ranging from 4.8 to 3280.4 ng/L and 6.6 to 6968 ng/L, respectively. High concentrations of pharmaceuticals were detected on the lower-stream sites as compared to upper-stream sites. |
| 英文关键词 | pharmaceutical residues ELISA lyophilisation and SPE UPLC-ESI-MS MS river water quality |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | South Africa |
| 开放获取类型 | gold, Green Published |
| 收录类别 | SCI-E ; SSCI |
| WOS记录号 | WOS:000542629600320 |
| WOS关键词 | PERFORMANCE LIQUID-CHROMATOGRAPHY ; LINKED-IMMUNOSORBENT-ASSAY ; TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; WASTE-WATER ; AQUATIC ENVIRONMENT ; TREATMENT PLANTS ; SEWAGE-SLUDGE ; RIVER WATER ; ANTIBIOTICS |
| WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health |
| WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/319601 |
| 作者单位 | 1.Rhodes Univ, Fac Pharm, Div Pharmaceut Chem, Environm Hlth & Biotechnol Res Grp, POB 94, ZA-6140 Grahamstown, South Africa; 2.Rhodes Univ, Fac Pharm, Div Pharmaceut, POB 94, ZA-6140 Grahamstown, South Africa |
| 推荐引用方式 GB/T 7714 | Vumazonke, Sesethu,Khamanga, Sandile Maswazi,Ngqwala, Nosiphiwe Patience. Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province[J],2020,17(11). |
| APA | Vumazonke, Sesethu,Khamanga, Sandile Maswazi,&Ngqwala, Nosiphiwe Patience.(2020).Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,17(11). |
| MLA | Vumazonke, Sesethu,et al."Detection of Pharmaceutical Residues in Surface Waters of the Eastern Cape Province".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17.11(2020). |
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