干旱区生态环境知识资源中心(Arid): Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods

Arid

DOI	10.3389/fpls.2020.00679
	Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods
	Romeis, Joerg 1; Widmer, Franco 2
通讯作者	Romeis, Joerg
来源期刊	FRONTIERS IN PLANT SCIENCE
ISSN	1664-462X
出版年	2020
卷号	11
英文摘要	RNA interference (RNAi) is a powerful technology that offers new opportunities for pest control through silencing of genes that are essential for the survival of arthropod pests. The approach relies on sequence-specificity of applied double-stranded (ds) RNA that can be designed to have a very narrow spectrum of both the target gene product (RNA) as well as the target organism, and thus allowing highly targeted pest control. Successful RNAi has been reported from a number of arthropod species belonging to various orders. Pest control may be achieved by applying dsRNA as foliar sprays. One of the main concerns related to the use of dsRNA is adverse environmental effects particularly on valued non-target species. Arthropods form an important part of the biodiversity in agricultural landscapes and contribute important ecosystem services. Consequently, environmental risk assessment (ERA) for potential impacts that plant protection products may have on valued non-target arthropods is legally required prior to their placement on the market. We describe how problem formulation can be used to set the context and to develop plausible pathways on how the application of dsRNA-based products could harm valued non-target arthropod species, such as those contributing to biological pest control. The current knowledge regarding the exposure to and the hazard posed by dsRNA in spray products for non-target arthropods is reviewed and suggestions are provided on how to select the most suitable test species and to conduct laboratory-based toxicity studies that provide robust, reliable and interpretable results to support the ERA.
英文关键词	ecosystem services environmental risk assessment hazard exposure pathways to harm problem formulation species selection tiered risk assessment
类型	Article
语种	英语
国家	Switzerland
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000542983100001
WOS关键词	DOUBLE-STRANDED-RNA ; WESTERN CORN-ROOTWORM ; GENETICALLY-MODIFIED CROPS ; PLANT-PROTECTION PRODUCTS ; ECOSYSTEM-SERVICES ; TARGETED ACTIVITY ; NEXT-GENERATION ; DESERT LOCUST ; ORAL RNAI ; IN-VIVO
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/319550
作者单位	1.Agroscope, Res Div Agroecol & Environm, Zurich, Switzerland; 2.Agroscope, Competence Div Method Dev & Analyt, Zurich, Switzerland
推荐引用方式 GB/T 7714	Romeis, Joerg,Widmer, Franco. Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods[J],2020,11.
APA	Romeis, Joerg,&Widmer, Franco.(2020).Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods.FRONTIERS IN PLANT SCIENCE,11.
MLA	Romeis, Joerg,et al."Assessing the Risks of Topically Applied dsRNA-Based Products to Non-target Arthropods".FRONTIERS IN PLANT SCIENCE 11(2020).