Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.3389/fphar.2020.00865 |
| Mining Sudanese Medicinal Plants for Antiprotozoal Agents | |
| Mahmoud, Abdelhalim Babiker1,2,3; Maser, Pascal1,2; Kaiser, Marcel1,2; Hamburger, Matthias2; Khalid, Sami3,4 | |
| 通讯作者 | Mahmoud, Abdelhalim Babiker |
| 来源期刊 | FRONTIERS IN PHARMACOLOGY
 |
| ISSN | 1663-9812 |
| 出版年 | 2020 |
| 卷号 | 11 |
| 英文摘要 | Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chagas disease, African trypansomiasis or leishmaniasis, and more than 200 million by malaria. Most of the currently available drugs have drawbacks in terms of toxicity, limited oral availability, development of resistance, or non-affordability. Tropical plants of the arid zones are a treasure chest for the discovery of bioactive secondary metabolites. This study aims to compile Sudanese medicinal plants, validate their antiprotozoal activities, and identify active molecules. We have performed a survey of medicinal plants of Sudan and selected 62 that are being used in Sudanese traditional medicine. From these, we collected materials such as leaves, stem, bark, or fruit. The plant materials were extracted in 70% ethanol and further fractionated by liquid-liquid partitioning using solvents of increasing polarity. This resulted in a library of 235 fractions. The library was testedin vitroagainstPlasmodium falciparum(erythrocytic stages),Trypanosoma brucei rhodesiense(bloodstream forms),Trypanosoma cruzi(intracellular amastigotes), andLeishmania donovani(axenic amastigotes). Active fractions were also tested for cytotoxicity. Of the 235 fractions, 125 showed growth inhibitory activity >80% at 10 mu g/ml, and >50% at 2 mu g/ml against at least one of the protozoan parasites.Plasmodium falciparumwas the most sensitive of the parasites, followed byT. b. rhodesienseandL. donovani. Only few hits were identified forT. cruzi, and these were not selective. Contrary to expectation based on phylogeny, but in agreement with previous results, a large number of extracts displayed mutual activity againstT. bruceiandP. falciparum. HPLC-based activity profiling for selected active extracts was performed to identify the bioactive principles. Active compounds identified by dereplication were guieranone A fromGuiera senegalensisJ.F.Gmel.; pseudosemiglabrin fromTephrosia apollinea(Delile) DC; ellagic acid and quercetin fromTerminalia leiocarpa(DC.) Baill.; and catechin, ethyl gallate, and epicatechin gallate fromVachellia nilotica(L.) P.J.H.Hurter & Mabb. Also the extracts ofCroton gratissimusvar.gratissimusandCuscuta hyalinaRoth ex Schult. exhibited promising antitrypanosomatid activity. This assessment provides a comprehensive overview of Sudanese medicinal plants and supports the notion that they are a potential source of bioactive molecules against protozoan parasites. |
| 英文关键词 | HPLC activity profiling drug discovery Sudan medicinal plant Trypanosoma Leishmania Plasmodium |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Switzerland ; Sudan |
| 开放获取类型 | Green Published, Green Accepted, gold |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000543516400001 |
| WOS关键词 | VITRO ANTIPLASMODIAL ACTIVITY ; TRYPANOSOMA-BRUCEI-RHODESIENSE ; VIVO ANTIMALARIAL ACTIVITY ; IN-VITRO ; PLASMODIUM-FALCIPARUM ; NATURAL-PRODUCTS ; ETHNOBOTANICAL SURVEY ; CHEMICAL-COMPOSITION ; GUIERA-SENEGALENSIS ; PHENOLIC-COMPOUNDS |
| WOS类目 | Pharmacology & Pharmacy |
| WOS研究方向 | Pharmacology & Pharmacy |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/319546 |
| 作者单位 | 1.Swiss Trop & Publ Hlth Inst, Parasite Chemotherapy Unit, Basel, Switzerland; 2.Univ Basel, Fac Sci, Basel, Switzerland; 3.Univ Khartoum, Fac Pharm, Khartoum, Sudan; 4.Univ Sci & Technol, Fac Pharm, Omdurman, Sudan |
| 推荐引用方式 GB/T 7714 | Mahmoud, Abdelhalim Babiker,Maser, Pascal,Kaiser, Marcel,et al. Mining Sudanese Medicinal Plants for Antiprotozoal Agents[J],2020,11. |
| APA | Mahmoud, Abdelhalim Babiker,Maser, Pascal,Kaiser, Marcel,Hamburger, Matthias,&Khalid, Sami.(2020).Mining Sudanese Medicinal Plants for Antiprotozoal Agents.FRONTIERS IN PHARMACOLOGY,11. |
| MLA | Mahmoud, Abdelhalim Babiker,et al."Mining Sudanese Medicinal Plants for Antiprotozoal Agents".FRONTIERS IN PHARMACOLOGY 11(2020). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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