干旱区生态环境知识资源中心(Arid): The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature

Arid

DOI	10.1007/s00404-020-05651-x
	The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature
	Rotem, Reut 1; Mastrolia, Salvatore Andrea 2; Rottenstreich, Misgav 1; Yohay, David 3; Weintraub, Adi Y.3
通讯作者	Rottenstreich, Misgav
来源期刊	ARCHIVES OF GYNECOLOGY AND OBSTETRICS
ISSN	0932-0067
EISSN	1432-0711
出版年	2020
卷号	302 期号:2 页码:321-328
英文摘要	Purpose Antibiotic treatment during surgical repair of obstetric anal sphincter injuries (OASIS) had been a matter of debate. We aimed to review the available literature regarding the efficacy of metronidazole administration in women undergoing perineal repair following obstetric OASIS. Study design To identify potentially eligible studies, we searched PubMed, Scopus, Embase and the Cochrane Library from inception to January 13th, 2019.Reference lists of identified studies were searched. No language restrictions were applied. We used a combination of keywords and text words represented by Metronidazole, obstetrics, obstetric anal sphincter injury, OASIS, third degree tear, fourth degree tear, third degree laceration, fourth degree laceration, antibiotic therapy, perineal damage and perineal trauma. Two reviewers independently screened the titles and abstracts of records retrieved from the database searches. Both reviewers recommended studies for the full-text review. Thescreen of full-text articles recommended by at least one reviewer was done independently by the same two reviewers and assessedfor inclusion in the systematic review. Disagreements between reviewers were resolved by consensus. Results The electronic database search yielded a total of 54,356 results (Fig. 1). After duplicate exclusion 28,154 references remained. Of them, 26 were relevant to the review based on title and abstract screening. None of these articles dealt with the use of metronidazole for the prevention of infections complicating anal sphincter repair in women with OASIS. A Cochrane review addressing antibiotic prophylaxis for patients following OASIS, compared prophylactic antibiotics against placebo or no antibiotics, included only one randomized controlled trial of 147 participants. This study showed that prophylactic antibiotics (not metronidazole) may be helpful to prevent perineal wound complications following OASIS. Fig. 1 Study seection process Conclusion Anaerobic infections potentially complicate wound repair after OASIS. Although scientific societies recommend the use of antibiotics for the prevention of infectious morbidity after OASIS, no study has specifically assessed the role of metronidazole.
英文关键词	Antibiotics Metronidazole OASIS Perineal damage Infections prevention
类型	Review
语种	英语
国家	Israel ; Italy
收录类别	SCI-E
WOS记录号	WOS:000541386600001
WOS关键词	RISK-FACTORS ; DELIVERY ; REPAIR ; OASIS
WOS类目	Obstetrics & Gynecology
WOS研究方向	Obstetrics & Gynecology
来源机构	Ben-Gurion University of the Negev ; Hebrew University of Jerusalem
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/319413
作者单位	1.Hebrew Univ Med Sch, Shaare Zedek Med Ctr, Dept Obstet & Gynecol, 12 Bayit St, IL-91031 Jerusalem, Israel; 2.Univ Milan, Osped Bambini Vittore Buzzi, Dept Obstet & Gynecol, Milan, Italy; 3.Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Dept Obstet & Gynecol, Beer Sheva, Israel
推荐引用方式 GB/T 7714	Rotem, Reut,Mastrolia, Salvatore Andrea,Rottenstreich, Misgav,et al. The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature[J]. Ben-Gurion University of the Negev, Hebrew University of Jerusalem,2020,302(2):321-328.
APA	Rotem, Reut,Mastrolia, Salvatore Andrea,Rottenstreich, Misgav,Yohay, David,&Weintraub, Adi Y..(2020).The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature.ARCHIVES OF GYNECOLOGY AND OBSTETRICS,302(2),321-328.
MLA	Rotem, Reut,et al."The use of metronidazole in women undergoing obstetric anal sphincter injuries: a systematic review of the literature".ARCHIVES OF GYNECOLOGY AND OBSTETRICS 302.2(2020):321-328.