干旱区生态环境知识资源中心(Arid): Determination of 19 anthelmintics in environmental water and sediment using an optimized PLE and SPE method coupled with UHPLC-MS/MS

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DOI	10.1016/j.scitotenv.2020.137516
	Determination of 19 anthelmintics in environmental water and sediment using an optimized PLE and SPE method coupled with UHPLC-MS/MS
	Li, Yiwen 1; Gan, Zhiwei 1; Liu, Yunxiang 1; Chen, Sibei 1; Su, Shijun 1; Ding, Sanglan 1; Ngoc Han Tran 2; Chen, Xi3 ; Long, Zhimin 3
通讯作者	Gan, Zhiwei
来源期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
EISSN	1879-1026
出版年	2020
卷号	719
英文摘要	A sensitive quantification method using pressurized liquid extraction (PLE) and solid phase extraction (SPE) coupled with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed for determination of 19 anthelmintic drugs (ADs) belonging to seven structural groups (Benzimidazoles, Diphenylsulfides, Imidazothiazoles, Hexahydropyrazines, Macrocylic lactones, Salicylanilides, Tetrahydropyrimidines) in environmental water and sediment samples. Eleven SPE cartridges, sample pH, elution solvents were tested to determine the optimal conditions for extraction. Among these investigated SPE types, the best recoveries for 19 target ADs were obtained from Oasis HLB cartridge with 37-102%, 45-103%, 37-88%, 28-82% and 31-90% for spiked river water, tap water, rainwater, wastewater, and sediment respectively (with RSD < 15%), except for closanteL The 19 ADs were separated within 10 min by a BEH C18 column and monitored in both positive and negative ions modes with switching electrospray ionization source. The cross-talk interferences were solved by identification of secondary mass spectrum of substances through MRM-IDA-EPI scanning using Qtrap. These interference peaks could be efficiently eliminated by setting MRM segments or using Qtrap to obtain tertiary fragmented information. The developed methods were satisfactory in terms of linearity, accuracy, and precision, and used eight isotopically labeled compounds as internal standards to correct matrix effects. Method quantification limit (MQL) for 19 ADs was below 1.1 ng/L, OA ng/L, 5.4 ng/L and 23 ng/g for river water, tap water, wastewater, and sediment, respectively. The validated method was successfully used to investigate the occurrence of anthelmintics in water and sediment samples from Chengdu, China. All ADs were detected in environment with the concentrations at ng/L level. (C) 2020 Elsevier B.V. All rights reserved.
英文关键词	Anthelmintics PLE SPE UHPLC-MS/MS Water Sediment
类型	Article
语种	英语
国家	Peoples R China ; Vietnam
收录类别	SCI-E
WOS记录号	WOS:000521936300041
WOS关键词	TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; PERSONAL CARE PRODUCTS ; MUNICIPAL WASTE-WATER ; LINEAR ION-TRAP ; PHARMACEUTICAL RESIDUES ; BENZIMIDAZOLE RESIDUES ; EMERGING CONTAMINANTS ; MULTIPLE CLASSES ; VETERINARY PHARMACEUTICALS
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/319286
作者单位	1.Sichuan Univ, Coll Architecture & Environm, Chengdu 610065, Peoples R China; 2.Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam; 3.Analyt Instrument Trading Co, SCIEX, Shanghai 200335, Peoples R China
推荐引用方式 GB/T 7714	Li, Yiwen,Gan, Zhiwei,Liu, Yunxiang,et al. Determination of 19 anthelmintics in environmental water and sediment using an optimized PLE and SPE method coupled with UHPLC-MS/MS[J],2020,719.
APA	Li, Yiwen.,Gan, Zhiwei.,Liu, Yunxiang.,Chen, Sibei.,Su, Shijun.,...&Long, Zhimin.(2020).Determination of 19 anthelmintics in environmental water and sediment using an optimized PLE and SPE method coupled with UHPLC-MS/MS.SCIENCE OF THE TOTAL ENVIRONMENT,719.
MLA	Li, Yiwen,et al."Determination of 19 anthelmintics in environmental water and sediment using an optimized PLE and SPE method coupled with UHPLC-MS/MS".SCIENCE OF THE TOTAL ENVIRONMENT 719(2020).