干旱区生态环境知识资源中心(Arid): Acute lower respiratory infections in Indigenous infants in Australia's Northern Territory across three eras of pneumococcal conjugate vaccine use (2006-15): a population-based cohort study

Arid

	Acute lower respiratory infections in Indigenous infants in Australia's Northern Territory across three eras of pneumococcal conjugate vaccine use (2006-15): a population-based cohort study
	Binks, Michael J.1; Beissbarth, Jemima 1; Oguoma, Victor M.1; Pizzutto, Susan J.1; Leach, Amanda J.1; Smith-Vaughan, Heidi C.1; McHugh, Lisa 2; Andrews, Ross M.2,3; Webby, Rosalind 4; Morris, Peter S.1,5; Chang, Anne B.1,6
通讯作者	Binks, Michael J.
来源期刊	LANCET CHILD & ADOLESCENT HEALTH
ISSN	2352-4642
出版年	2020
卷号	4 期号:6 页码:425-434
英文摘要	Background The burden of acute lower respiratory infection (ALRI) in Indigenous children of Australia's Northern Territory is among the highest globally. No published data exists on the effect of pneumococcal conjugate vaccine (PCV) introduction on ALRIs in this population beyond 2005. The aim of this study was to describe the rates of ALRI admissions to hospital in Indigenous infants in the Northern Territory from 2006 to 2015, across three periods of different PCV use. We hypothesised that broader valency PCVs would be more effective against hospitalisations for pneumonia. Methods We did a retrospective population-based cohort study of Indigenous infants born in the Northern Territory followed up until age 12 months. Data were from administrative hospital and perinatal datasets. International classification of diseases codes (tenth revision, Australian modification; ICD-10AM) were used to identify respiratory hospitalisations of interest: all-cause ALRI, all-cause pneumonia, bacterial pneumonia, viral pneumonia, influenza-like illness (ILI), respiratory syncytial virus ALRI (RSV-ALRI), and pneumococcal ALRI. Incidence rates were compared between PCV eras (7-valent PCV [PCV7], 2006-09; 10-valent PCV [PCV10], 2009-11; and 13-valent PCV [PCV13], 2011-15) using interrupted time trend analysis and negative binomial regression. Findings For children born between Jan 1, 2006, and Dec 31, 2015, 4138 ALRI episodes (31% of all hospitalisations) occurred among 2888 (20%) of the 14 594 infants. The overall ALRI hospitalisation rate was 29.7 episodes per 100 child-years. Prominent risk factors associated with ALRI hospitalisation were living in a remote community or the Central desert region, being born preterm or with low birthweight. ALRI rates were lowest in the PCV13 era, in association with a significant reduction in bacterial pneumonia hospitalisations in the PCV13 era compared with the PCV10 (incidence rate ratio 0.68, 95% CI 0.57-0.81) and PCV7 (0.70, 0.60-0.81) eras. In contrast, RSV-ALRI rates were 4.9 episodes per 100 child-years in each era. Interpretation A 30% reduction in bacterial-coded pneumonia hospitalisations in the Northern Territory during the era of PCV13 immunisation supports its ongoing use in the region. Despite the reduction, one in five Indigenous infants born in the region continue to be hospitalised with an ALRI in their first year of life. Future gains require multifaceted environmental and biomedical approaches.
类型	Article
语种	英语
国家	Australia
收录类别	SCI-E
WOS记录号	WOS:000536732100017
WOS关键词	RADIOLOGICALLY-CONFIRMED PNEUMONIA ; OTITIS-MEDIA ; CONTROLLED-TRIAL ; CHILDREN ; DISEASE ; IMPACT ; HOSPITALIZATIONS ; 10-VALENT ; HEALTH
WOS类目	Pediatrics
WOS研究方向	Pediatrics
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/319219
作者单位	1.Charles Darwin Univ, Menzies Sch Hlth Res, Child Hlth Div, Darwin, NT, Australia; 2.Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia; 3.Australian Natl Univ, Res Sch Populat Hlth, Canberra, ACT, Australia; 4.Ctr Dis Control, Dept Hlth, Darwin, NT, Australia; 5.Royal Darwin Hosp, Dept Paediat, Darwin, NT, Australia; 6.Queensland Univ Technol, Queensland Childrens Hosp, Ctr Childrens Hlth Res, Dept Resp & Sleep Med, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Binks, Michael J.,Beissbarth, Jemima,Oguoma, Victor M.,et al. Acute lower respiratory infections in Indigenous infants in Australia's Northern Territory across three eras of pneumococcal conjugate vaccine use (2006-15): a population-based cohort study[J],2020,4(6):425-434.
APA	Binks, Michael J..,Beissbarth, Jemima.,Oguoma, Victor M..,Pizzutto, Susan J..,Leach, Amanda J..,...&Chang, Anne B..(2020).Acute lower respiratory infections in Indigenous infants in Australia's Northern Territory across three eras of pneumococcal conjugate vaccine use (2006-15): a population-based cohort study.LANCET CHILD & ADOLESCENT HEALTH,4(6),425-434.
MLA	Binks, Michael J.,et al."Acute lower respiratory infections in Indigenous infants in Australia's Northern Territory across three eras of pneumococcal conjugate vaccine use (2006-15): a population-based cohort study".LANCET CHILD & ADOLESCENT HEALTH 4.6(2020):425-434.