干旱区生态环境知识资源中心(Arid): Differential navigational strategies during spatial learning in a new modified version of the Oasis maze

Arid

DOI	10.1016/j.bbr.2020.112555
	Differential navigational strategies during spatial learning in a new modified version of the Oasis maze
	Concha-Miranda, Miguel 1,2; More, Jamileth 2,3; Grinspun, Noemi 1,2; Sanchez, Cristian 1,2; Paula-Lima, Andrea 2,4; Valdes, Jose L.1,2
通讯作者	Valdes, Jose L.
来源期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
EISSN	1872-7549
出版年	2020
卷号	385
英文摘要	During spatial navigation, some typical parameters of learning have been observed, such as latency or path length. However, these parameters are sensitive to patterns of navigation and orientation that are not easily measurable. In the present study, we used a modified version of the Oasis maze and evaluated different parameters of learning, navigation, and orientation in different animal groups. Through a PCA (Principal component analysis) we found different factors such as learning, navigation, speediness, anxiety, orientation, path variability, and turning behavior. Each factor gathers different groups of behavioral variables. ANOVA analysis of those factors demonstrates that some of them are more strongly modulated by trial progression, while others by animal group differences, indicating that each group of variables is better reflecting one of these dimensions. To understand the nature of these navigation differences, we studied orientation strategies between animal conditions and across trials. We found that the main navigational strategy used by the animals consist of locating the target and directing their behaviors towards this area. When testing how this strategy changed after cognitive impairment or enhancement, we found that A beta Os treated animals (Amyloid beta Oligomers, Alzheimer animal model) have strong orientation difficulties at locating the target at longer distances. While animals with learning enhancement (exercised rat) do not show changes in orientation behaviors. These analyses highlight that experimental manipulations affect learning, but also induced changes in the navigational strategies. We concluded that both dimensions can explain the differences observed in typical learning variables, such as latency or path length, motivating the development of new tools that asses this two-dimension as a separate but, interacting phenomenon.
英文关键词	Spatial learning Navigation Orientation Hippocampus PCA analysis
类型	Article
语种	英语
国家	Chile
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000526067900001
WOS关键词	MORRIS WATER MAZE ; MEMORY ; BEHAVIOR ; RATS ; HIPPOCAMPUS ; PATH ; RECOGNITION ; ORIENTATION ; COMPONENTS ; ANXIETY
WOS类目	Behavioral Sciences ; Neurosciences
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/319114
作者单位	1.Univ Chile, Fac Med, Dept Neurosci, Avda Independencia 1027, Santiago, Chile; 2.Univ Chile, Fac Med, BNI, Santiago, Chile; 3.Hosp Clin Univ Chile, CICA, Santiago, Chile; 4.Univ Chile, Fac Dent, Inst Res Dent Sci, Santiago, Chile
推荐引用方式 GB/T 7714	Concha-Miranda, Miguel,More, Jamileth,Grinspun, Noemi,et al. Differential navigational strategies during spatial learning in a new modified version of the Oasis maze[J],2020,385.
APA	Concha-Miranda, Miguel,More, Jamileth,Grinspun, Noemi,Sanchez, Cristian,Paula-Lima, Andrea,&Valdes, Jose L..(2020).Differential navigational strategies during spatial learning in a new modified version of the Oasis maze.BEHAVIOURAL BRAIN RESEARCH,385.
MLA	Concha-Miranda, Miguel,et al."Differential navigational strategies during spatial learning in a new modified version of the Oasis maze".BEHAVIOURAL BRAIN RESEARCH 385(2020).