干旱区生态环境知识资源中心(Arid): Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial

Arid

DOI	10.1016/j.cct.2020.105965
	Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial
	Hoge, Elizabeth A.1; Bui, Eric 2,3; Mete, Mihriye 1,4; Philip, Samantha R.1; Gabriel, Caroline 1; Ward, Meredith J.2; Suzuki, Rebecca 5; Dutton, Mary Ann 1; Simon, Naomi M.5
通讯作者	Hoge, Elizabeth A.
来源期刊	CONTEMPORARY CLINICAL TRIALS
ISSN	1551-7144
EISSN	1559-2030
出版年	2020
卷号	91
英文摘要	Anxiety disorders (generalized anxiety disorder, social anxiety disorder, panic disorder, and agoraphobia) are common, distressing, and impairing. While pharmacotherapy and psychotherapy are first-line treatment strategies for anxiety disorders, many patients are reluctant to take psychiatric medication, and many prefer to avoid any kind of mental health treatment due to stigma or distrust of traditional medical care. We present the trial protocol for the first study comparing first-line medication treatment with Mindfulness-Based Stress Reduction (MBSR), a popular mindfulness meditation training program, for the treatment of anxiety disorders. We will use a non-inferiority, comparative effectiveness trial design, in which individuals with diagnosed anxiety disorders will be randomized to either pharmacotherapy with escitalopram or MBSR for 8 weeks of treatment. Treatment outcome will be based on gold standard symptom severity measures assessed by trained independent evaluators blind to treatment allocation. Secondary outcomes will include key symptom and function measures, as well as tolerability and satisfaction with treatment. Findings will provide crucial information to inform decision making about the relative benefits of MBSR versus a first line medication for anxiety disorders by patients, medical care providers, healthcare insurers and other stakeholders.
英文关键词	Anxiety Anxiety disorder Mindfulness meditation Escitalopram Social anxiety Worry
类型	Article
语种	英语
国家	USA
收录类别	SCI-E ; SSCI
WOS记录号	WOS:000537083100008
WOS关键词	CLINICALLY IMPORTANT DIFFERENCE ; HEALTH-ORGANIZATION HEALTH ; IMPAIRMENT SCALE OASIS ; PANIC DISORDER ; PSYCHOMETRIC PROPERTIES ; WORK PERFORMANCE ; PRIMARY-CARE ; DOUBLE-BLIND ; SEVERITY ; STRESS
WOS类目	Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318960
作者单位	1.Georgetown Univ, Med Ctr, Dept Psychiat, Washington, DC 20007 USA; 2.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA; 3.Harvard Med Sch, Boston, MA 02115 USA; 4.MedStar Hlth Res Inst, Hyattsville, MD USA; 5.NYU, Sch Med, Dept Psychiat, NYU Langone Hlth, New York, NY USA
推荐引用方式 GB/T 7714	Hoge, Elizabeth A.,Bui, Eric,Mete, Mihriye,et al. Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial[J],2020,91.
APA	Hoge, Elizabeth A..,Bui, Eric.,Mete, Mihriye.,Philip, Samantha R..,Gabriel, Caroline.,...&Simon, Naomi M..(2020).Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial.CONTEMPORARY CLINICAL TRIALS,91.
MLA	Hoge, Elizabeth A.,et al."Treatment for anxiety: Mindfulness meditation versus escitalopram (TAME): Design of a randomized, controlled non-inferiority trial".CONTEMPORARY CLINICAL TRIALS 91(2020).