干旱区生态环境知识资源中心(Arid): Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice

Arid

DOI	10.3748/wjg.v26.i12.1286
	Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice
	Wang, Zhi-Dan 1; Zhang, Yu 2,3; Dai, Yi-Dan 1; Ren, Ke 1; Han, Chen 2,3; Wang, Heng-Xiao 2,3; Yi, Shuang-Qin 1
通讯作者	Yi, Shuang-Qin
来源期刊	WORLD JOURNAL OF GASTROENTEROLOGY
ISSN	1007-9327
EISSN	2219-2840
出版年	2020
卷号	26 期号:12 页码:1286-1297
英文摘要	BACKGROUND Tamarix chinensis Lour (TCL) is a shrub that usually grows in arid or semiarid desert areas and saline-alkali fields. It is a traditional Chinese herbal medicine with hepatoprotective, antioxidant, antibacterial, and antitumor activities. AIM To investigate the possible protective effects of TCL against liver injury induced by chronic ethanol intake. METHODS C57BL/6J male mice were fed a Lieber-DeCarli lipid diet containing alcohol and received (by gavage) a water-alcohol extract (80%) of TCL (100 and 200 mg/kg BW) or distilled water for 4 wk. After euthanasia, liver tissues were observed histologically with hematoxylin and eosin staining and Oil red O staining, and the levels of alanine aminotransferase, aspartate transaminase, hepatic lipids, reactive oxygen species, malondialdehyde, and superoxide dismutase were measured. In addition, expression of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome and downstream proinflammatory cytokines were determined. RESULTS Compared with the ethanol group, mice in the TCL-treated group (200 mg/kg) had significantly lower serum levels of alanine aminotransferase (mean, 34.1 IU/L vs 45.3 IU/L, P < 0.01) and aspartate transaminase (mean, 89.6 IU/L vs 115.7 IU/L, P < 0.01), as well as marked reduction of hepatic tissue reactive oxygen species (decreased by 27.5%, P < 0.01) and malondialdehyde (decreased by 76.6%, P < 0.01) levels, with a significant increase of superoxide dismutase (Increased by 73.2%, P < 0.01). Expression of the NLRP3 inflammasome and its downstream cytokines [interleukin (IL)-1 beta, tumor necrosis factor-alpha, and IL-6], and recruitment of natural killer T cells to the liver, were reduced in the TCL-treated incubation with a Lieber-DeCaril ethanol lipid diet group. CONCLUSION These findings suggest that a TCL extract (200 mg/kg) protects against chronic ethanol-induced liver injury, probably by inhibiting the NLRP3-caspase-1-IL-1 beta signaling pathway and suppressing oxidative stress.
英文关键词	Tamarix chinensis Lour Alcoholic liver disease Ethanol-induced liver injury NLRP3 inflammasome Oxidative stress Natural killer T cells
类型	Article
语种	英语
国家	Japan ; Peoples R China
开放获取类型	Green Published, hybrid
收录类别	SCI-E
WOS记录号	WOS:000536262100005
WOS关键词	IL-1 RECEPTOR ANTAGONIST ; NLRP3 INFLAMMASOME ; HEPATIC STEATOSIS ; OXIDATIVE STRESS ; STEATOHEPATITIS ; ANTIOXIDANT ; ACTIVATION ; LEAVES
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318900
作者单位	1.Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Lab Funct Morphol, Tokyo 1168551, Japan; 2.Shandong First Med Univ, Inst Basic Med, Jinan 250062, Shandong, Peoples R China; 3.Shandong Acad Med Sci, Jinan 250062, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhi-Dan,Zhang, Yu,Dai, Yi-Dan,et al. Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice[J],2020,26(12):1286-1297.
APA	Wang, Zhi-Dan.,Zhang, Yu.,Dai, Yi-Dan.,Ren, Ke.,Han, Chen.,...&Yi, Shuang-Qin.(2020).Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice.WORLD JOURNAL OF GASTROENTEROLOGY,26(12),1286-1297.
MLA	Wang, Zhi-Dan,et al."Tamarix chinensis Lour inhibits chronic ethanol-induced liver injury in mice".WORLD JOURNAL OF GASTROENTEROLOGY 26.12(2020):1286-1297.