干旱区生态环境知识资源中心(Arid): The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert

Arid

DOI	10.3390/genes11030312
	The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert
	Gu, Yan 1,2,3; Lin, Xiaozeng 1,2,3; Kapoor, Anil 1,2,4; Chow, Mathilda Jing 1,2,3; Jiang, Yanzhi 1,2,3; Zhao, Kuncheng 1,2,3; Tang, Damu 1,2,3
通讯作者	Tang, Damu
来源期刊	GENES
EISSN	2073-4425
出版年	2020
卷号	11 期号:3
英文摘要	FAM84B is a risk gene in breast and prostate cancers. Its upregulation is associated with poor prognosis of prostate cancer, breast cancer, and esophageal squamous cell carcinoma. FAM84B facilitates cancer cell proliferation and invasion in vitro, and xenograft growth in vivo. The FAM84B and Myc genes border a 1.2 Mb gene desert at 8q24.21. Co-amplification of both occurs in 20 cancer types. Mice deficient of a 430 Kb fragment within the 1.2 Mb gene desert have downregulated FAM84B and Myc expressions concurrent with reduced breast cancer growth. Intriguingly, Myc works in partnership with other oncogenes, including Ras. FAM84B shares similarities with the H-Ras-like suppressor (HRASLS) family over their typical LRAT (lecithin:retinal acyltransferase) domain. This domain contains a catalytic triad, H23, H35, and C113, which constitutes the phospholipase A(1/2) and O-acyltransferase activities of HRASLS1-5. These enzymatic activities underlie their suppression of Ras. FAM84B conserves H23 and H35 but not C113 with both histidine residues residing within a highly conserved motif that FAM84B shares with HRASLS1-5. Deletion of this motif abolishes FAM84B oncogenic activities. These properties suggest a collaboration of FAM84B with Myc, consistent with the role of the gene desert in strengthening Myc functions. Here, we will discuss recent research on FAM84B-derived oncogenic potential.
英文关键词	FAM84B Myc 8q24 21 gene desert H-Ras-like suppressor (HRASLS) Ras tumorigenesis
类型	Review
语种	英语
国家	Canada
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000529189000076
WOS关键词	GENOME-WIDE ASSOCIATION ; LONG NONCODING RNA ; CANCER RISK LOCUS ; PROSTATE-CANCER ; C-MYC ; BREAST-CANCER ; COLORECTAL-CANCER ; ESOPHAGEAL-CARCINOMA ; PROGRESSION MARKERS ; RANGE INTERACTION
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318873
作者单位	1.St Josephs Hosp, UCCRI, Hamilton, ON L8N 4A6, Canada; 2.McMaster Univ, Dept Surg, Hamilton, ON L8S 4K1, Canada; 3.St Josephs Hosp, Res Inst St Joes Hamilton, Hamilton, ON L8N 4A6, Canada; 4.McMaster Univ, Dept Med, Hamilton, ON L8S 4K1, Canada
推荐引用方式 GB/T 7714	Gu, Yan,Lin, Xiaozeng,Kapoor, Anil,et al. The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert[J],2020,11(3).
APA	Gu, Yan.,Lin, Xiaozeng.,Kapoor, Anil.,Chow, Mathilda Jing.,Jiang, Yanzhi.,...&Tang, Damu.(2020).The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert.GENES,11(3).
MLA	Gu, Yan,et al."The Oncogenic Potential of the Centromeric Border Protein FAM84B of the 8q24.21 Gene Desert".GENES 11.3(2020).