干旱区生态环境知识资源中心(Arid): A clinically important, plasmid-borne antibiotic resistance gene (beta-lactamase TEM-116) present in desert soils

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DOI	10.1016/j.scitotenv.2020.137497
	A clinically important, plasmid-borne antibiotic resistance gene (beta-lactamase TEM-116) present in desert soils
	Naidoo, Yashini 1; Valverde, Angel 2; Cason, Errol D.3; Pierneef, Rian E.4; Cowan, Don A.1
通讯作者	Cowan, Don A.
来源期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
EISSN	1879-1026
出版年	2020
卷号	719
英文摘要	The exhaustive use of antibiotics in humans, animal farming and other agricultural practices has resulted in the frequent appearance of antibiotic resistant bacteria in human-impacted habitats. However, antibiotic resistance in natural (less-impacted) habitats is less understood. Using shotgun metagenomics we analysed soils from relatively low anthropogenic impact sites across the Namib Desert. We report the presence of a clinically significant extended spectrum D-lactamase (TEM-116), on a ColE1-like plasm id also carrying a metal resistance gene (arsC). The co-occurrence of resistance to antimicrobial drugs and metals encoded on a single mobile genetic element increases the probability of dissemination of these resistance determinants and the potential selection of multiple resistance mechanisms. In addition, the presence of a P7 entero-bacteriophage on the same plasmid, may represent a new vehicle for the propagation of TEM-116 in these soil communities. These findings highlight the role of the environment in the One Health initiative. (C) 2020 Elsevier B.V. All rights reserved.
英文关键词	Metagenomics Low anthropogenic impact Namib desert Mobile genetic element
类型	Article
语种	英语
国家	South Africa
收录类别	SCI-E
WOS记录号	WOS:000521936300001
WOS关键词	HOST-RANGE PLASMIDS ; ESCHERICHIA-COLI ; METAL RESISTANCE ; MOLECULAR CHARACTERIZATION ; KLEBSIELLA-PNEUMONIAE ; BACTERIA ; INDICATORS ; SOUTH ; ENTEROBACTERIACEAE ; ENVIRONMENT
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318767
作者单位	1.Univ Pretoria, Dept Biochem Genet & Microbiol, Lynnwood Rd, ZA-0002 Pretoria, South Africa; 2.Univ Free State, Dept Microbial Biochem & Food Technol, Nelson Mandela Dr, ZA-9300 Bloemfontein, South Africa; 3.Univ Free State, Dept Anim Wildlife & Grassland Sci, Nelson Mandela Dr, ZA-9300 Bloemfontein, South Africa; 4.Agr Res Council, Biotechnol Platform, Soutpan Rd,Onderstepoort Campus, ZA-0110 Pretoria, South Africa
推荐引用方式 GB/T 7714	Naidoo, Yashini,Valverde, Angel,Cason, Errol D.,et al. A clinically important, plasmid-borne antibiotic resistance gene (beta-lactamase TEM-116) present in desert soils[J],2020,719.
APA	Naidoo, Yashini,Valverde, Angel,Cason, Errol D.,Pierneef, Rian E.,&Cowan, Don A..(2020).A clinically important, plasmid-borne antibiotic resistance gene (beta-lactamase TEM-116) present in desert soils.SCIENCE OF THE TOTAL ENVIRONMENT,719.
MLA	Naidoo, Yashini,et al."A clinically important, plasmid-borne antibiotic resistance gene (beta-lactamase TEM-116) present in desert soils".SCIENCE OF THE TOTAL ENVIRONMENT 719(2020).