干旱区生态环境知识资源中心(Arid): Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges

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DOI	10.3389/fpls.2020.00451
	Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges
	Christiaens, Olivier 1; Whyard, Steve 2; Velez, Ana M.3; Smagghe, Guy 1
通讯作者	Velez, Ana M.
来源期刊	FRONTIERS IN PLANT SCIENCE
ISSN	1664-462X
出版年	2020
卷号	11
英文摘要	Exploiting the RNA interference (RNAi) gene mechanism to silence essential genes in pest insects, leading to toxic effects, has surfaced as a promising new control strategy in the past decade. While the first commercial RNAi-based products are currently coming to market, the application against a wide range of insect species is still hindered by a number of challenges. In this review, we discuss the current status of these RNAi-based products and the different delivery strategies by which insects can be targeted by the RNAi-triggering double-stranded RNA (dsRNA) molecules. Furthermore, this review also addresses a number of physiological and cellular barriers, which can lead to decreased RNAi efficacy in insects. Finally, novel non-transgenic delivery technologies, such as polymer or liposomic nanoparticles, peptide-based delivery vehicles and viral-like particles, are also discussed, as these could overcome these barriers and lead to effective RNAi-based pest control.
英文关键词	RNA interference RNAi pest management insect pests dsRNA host-induced gene silencing (HIGS) spray-induced gene silencing (SIGS) virus-induced gene silencing (VIGS)
类型	Review
语种	英语
国家	Belgium ; Canada ; USA
开放获取类型	Green Published, gold
收录类别	SCI-E
WOS记录号	WOS:000531619000001
WOS关键词	WESTERN CORN-ROOTWORM ; DIABROTICA-VIRGIFERA-VIRGIFERA ; COLORADO POTATO BEETLE ; LEPTINOTARSA-DECEMLINEATA ; DESERT LOCUST ; SYSTEMIC RNAI ; INTERFERENCE RESPONSE ; NUCLEASE ACTIVITY ; RISK-ASSESSMENT ; ORAL RNAI
WOS类目	Plant Sciences
WOS研究方向	Plant Sciences
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318580
作者单位	1.Univ Ghent, Dept Plants & Crops, Ghent, Belgium; 2.Univ Manitoba, Dept Biol Sci, Winnipeg, MB, Canada; 3.Univ Nebraska, Dept Entomol, Lincoln, NE 68583 USA
推荐引用方式 GB/T 7714	Christiaens, Olivier,Whyard, Steve,Velez, Ana M.,et al. Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges[J],2020,11.
APA	Christiaens, Olivier,Whyard, Steve,Velez, Ana M.,&Smagghe, Guy.(2020).Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges.FRONTIERS IN PLANT SCIENCE,11.
MLA	Christiaens, Olivier,et al."Double-Stranded RNA Technology to Control Insect Pests: Current Status and Challenges".FRONTIERS IN PLANT SCIENCE 11(2020).