干旱区生态环境知识资源中心(Arid): Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats

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DOI	10.3923/ijp.2020.310.318
	Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats
	Elgebaly, Hassan 1; Germoush, Mousa 1; Mosa, Nermeen 1; Zahou, Fatin 1; Soffar, Ahmed 1,2; Alotaibi, Nasser 3; Qarmush, Moath 4; Hussein, Omnia 5; Bin-Jumah, May 6; Hassanein, Emad 7; Hernandez-Bautista, Rene 8; Mahmoud, Ayman M.5
通讯作者	Mahmoud, Ayman M.
来源期刊	INTERNATIONAL JOURNAL OF PHARMACOLOGY
ISSN	1811-7775
EISSN	1812-5700
出版年	2020
卷号	16 期号:4 页码:310-318
英文摘要	Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg(-1) STZ. Diabetic rats received 250 and 500 mg kg(-1) AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AGE effectively inhibited diabetes-induced testicular tissue injuryand prevented inflammatoryand apoptotic responses manifested by decreased TNF-alpha, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AGE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.
英文关键词	Desert rose oxidative injury inflammation antioxidants phenolics diabetes testosterone apoptosis
类型	Article
语种	英语
国家	Saudi Arabia ; Egypt ; Germany
收录类别	SCI-E
WOS记录号	WOS:000534611100004
WOS关键词	GERM-CELL DEATH ; MELLITUS ; INFLAMMATION ; DAMAGE ; APOPTOSIS ; ACTIVATION ; PROTECTS ; TAURINE ; ROEM.
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/318479
作者单位	1.Jouf Univ, Coll Sci, Dept Biol, Sakakah, Saudi Arabia; 2.Alexandria Univ, Fac Sci, Dept Zool, Alexandria, Egypt; 3.Jouf Univ, Coll Sci, Dept Chem, Sakakah, Saudi Arabia; 4.Jouf Univ, Coll Med, Sakakah, Saudi Arabia; 5.Beni Suef Univ, Fac Sci, Dept Zool, Physiol Div, Salah Salim St, Bani Suwayf 62514, Egypt; 6.Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh, Saudi Arabia; 7.Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Assiut Branch, Cairo, Egypt; 8.Helmholtz Ctr Munich, Inst Diabet & Obes, Neuherberg, Germany
推荐引用方式 GB/T 7714	Elgebaly, Hassan,Germoush, Mousa,Mosa, Nermeen,et al. Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats[J],2020,16(4):310-318.
APA	Elgebaly, Hassan.,Germoush, Mousa.,Mosa, Nermeen.,Zahou, Fatin.,Soffar, Ahmed.,...&Mahmoud, Ayman M..(2020).Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats.INTERNATIONAL JOURNAL OF PHARMACOLOGY,16(4),310-318.
MLA	Elgebaly, Hassan,et al."Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats".INTERNATIONAL JOURNAL OF PHARMACOLOGY 16.4(2020):310-318.