干旱区生态环境知识资源中心(Arid): Simultaneous determination of twelve paralytic shellfish poisoning toxins in bivalve molluscs by UPLC-MS/MS and its applications to a food poisoning incident

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DOI	10.1016/j.toxicon.2019.11.012
	Simultaneous determination of twelve paralytic shellfish poisoning toxins in bivalve molluscs by UPLC-MS/MS and its applications to a food poisoning incident
	Huang, Hong-Nan 1,2; Lu, Jia-Li 1,2; Lin, Shou-Er 1; Zheng, Ren-Jin 1; Lin, Jie 1,2
通讯作者	Lin, Jie
来源期刊	TOXICON
ISSN	0041-0101
出版年	2020
卷号	174 页码:1-7
英文摘要	In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was originally developed for simultaneously quantitative analysis of twelve paralytic shellfish poisoning toxins, referring to STX, NEO, dcSTX, GTX1, GTX2, GTX3, GTX4, GTX5, C1, C2, dcGTX2, and dcGTX3 in bivalve molluscs. Chromatographic separations were performed on a TSK-Gel Amide-80 column (5 mu m, 2.0 x 150 mu m, Tosoh Corporation) by gradient elution with 2 mmol L-1 ammonium formate solution-acetonitrile (containing 0.1% formic acid) as mobile phases. The samples were pretreated by extraction with acetonitrile-water (80:20, v/v; containing 0.1% formic acid), followed by cleaning up using an Oasis HLB extraction cartridge (500 mg/6 mL). The present method showed good linearity (r(2) > 0.99) with the limits of detection (LODs) and limits of quantification (LOQs) ranged from 1.03 to 10.65 mu g/kg and 3.43-35.46 mu g/kg, respectively for these toxins. Owing to its sensitivity and rapid properties, the presented method was applied to the determination of PSP toxins in bivalve molluscs involved in a food poisoning incident occurred in Zhangzhou, China, in June 2017.
英文关键词	Bivalve molluscs Paralytic shellfish poisoning toxins Food poisoning UPLC-MS/MS
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000512221400001
WOS关键词	CHROMATOGRAPHY-MASS SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; QUANTITATIVE-DETERMINATION ; PSP TOXINS ; QUANTIFICATION ; OPTIMIZATION ; SAXITOXIN
WOS类目	Pharmacology & Pharmacy ; Toxicology
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315675
作者单位	1.Fujian Ctr Dis Prevent & Control, Fujian Prov Key Lab Zoonosis Res, Fuzhou 350001, Peoples R China; 2.Fujian Med Univ, Sch Pharm, Fuzhou 350122, Peoples R China
推荐引用方式 GB/T 7714	Huang, Hong-Nan,Lu, Jia-Li,Lin, Shou-Er,et al. Simultaneous determination of twelve paralytic shellfish poisoning toxins in bivalve molluscs by UPLC-MS/MS and its applications to a food poisoning incident[J],2020,174:1-7.
APA	Huang, Hong-Nan,Lu, Jia-Li,Lin, Shou-Er,Zheng, Ren-Jin,&Lin, Jie.(2020).Simultaneous determination of twelve paralytic shellfish poisoning toxins in bivalve molluscs by UPLC-MS/MS and its applications to a food poisoning incident.TOXICON,174,1-7.
MLA	Huang, Hong-Nan,et al."Simultaneous determination of twelve paralytic shellfish poisoning toxins in bivalve molluscs by UPLC-MS/MS and its applications to a food poisoning incident".TOXICON 174(2020):1-7.