干旱区生态环境知识资源中心(Arid): Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples

Arid

DOI	10.1016/j.talanta.2019.120652
	Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples
	Ma, Jian-Bo 1; Wu, Hong-Wei 2; Liao, Yu-Feng 1; Rui, Qiu-Hong 1; Zhu, Yan 3; Zhang, Yun 3
通讯作者	Zhu, Yan ; Zhang, Yun
来源期刊	TALANTA
ISSN	0039-9140
EISSN	1873-3573
出版年	2020
卷号	210
英文摘要	Here, the novel petal-shaped ionic liquids modified covalent organic frameworks (PS-IL-COFs) particles have been synthesized by using ionic liquids as modifying agent, which could be beneficial to avoid the aggregation of COFs during the preparation and improve its dispersing performance. The novel PS-IL-COFs particles have been used and evaluated in the one step cleanup and extraction (OSCE) procedure for human plasma prior to the analysis of 3 general anesthetics by liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS). In the OSCE procedure, human plasma samples are directly mixed with extraction solvent and PS-IL-COFs particles, and the extraction and cleanup procedure have been carried out simultaneously. Compared with the Oasis PRiME HLB cartridge method, the OSCE procedure using PS-IL-COFs particles as sorbents is much more effective for the minimization of ion suppression resulted from blood phospholipids. Under optimal conditions, the PS-IL-COFs particles show higher cleanup efficiency of 3 general anesthetics with recoveries in the range of 82.5%-115%. The limits of quantification (LOQs) for propofol, ketamine and etomidate are 0.18 mu g/L, 0.15 mu g/L and 0.016 mu g/L, respectively. Validation results on linearity, specificity, precision and trueness, as well as on the application to analysis of general anesthetics in a case of a 54-year-old female suffered gallstone demonstrate the applicability to clinical studies.
英文关键词	One step cleanup and extraction (OSCE) procedure Petal-shaped ionic liquids modified covalent organic frameworks (PS-IL-COFs) Human plasma Liquid chromatography-tandem quadrupole mass spectrometry (LC-MS/MS) General anesthetics
类型	Article
语种	英语
国家	Peoples R China
收录类别	SCI-E
WOS记录号	WOS:000514230600040
WOS关键词	SOLID-PHASE EXTRACTION ; PASS-THROUGH CLEANUP ; MASS-SPECTROMETRY ; HUMAN SERUM ; LC-MS/MS ; CHROMATOGRAPHY ; QUANTIFICATION ; MICROEXTRACTION ; ENRICHMENT ; DRUGS
WOS类目	Chemistry, Analytical
WOS研究方向	Chemistry
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/315646
作者单位	1.Univ Chinese Acad Sci, HwaMei Hosp, Ningbo 315010, Zhejiang, Peoples R China; 2.Xinxiang Med Univ, Dept Chem, Xinxiang 453003, Henan, Peoples R China; 3.Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Ma, Jian-Bo,Wu, Hong-Wei,Liao, Yu-Feng,et al. Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples[J],2020,210.
APA	Ma, Jian-Bo,Wu, Hong-Wei,Liao, Yu-Feng,Rui, Qiu-Hong,Zhu, Yan,&Zhang, Yun.(2020).Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples.TALANTA,210.
MLA	Ma, Jian-Bo,et al."Application of petal-shaped ionic liquids modified covalent organic frameworks for one step cleanup and extraction of general anesthetics in human plasma samples".TALANTA 210(2020).